{"id":"W4280489063","doi":"10.1007/s12032-022-01695-y","title":"Cell line models for drug discovery in PIK3CA-mutated colorectal cancers","year":2022,"lang":"en","type":"article","venue":"Medical Oncology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"NOSM University; Essar Steel Algoma (Canada); Sault Area Hospital","funders":"","keywords":"KRAS; Colorectal cancer; Cancer research; Microsatellite instability; Cancer; Cell culture; PI3K/AKT/mTOR pathway; Mutation; Trametinib; Medicine; Biology; Internal medicine; Oncology; Genetics; MAPK/ERK pathway; Kinase; Gene; Signal transduction; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006983381,0.0001533919,0.0002926693,0.00006291767,0.00009698499,0.000007357523,0.0004006271,0.0002151641,0.0002469048],"category_scores_gemma":[0.0001711824,0.0001544486,0.000102865,0.0001522548,0.0001653583,0.000005219307,0.0002981819,0.0003605655,0.000001958968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000529012,"about_ca_system_score_gemma":0.001923255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003542908,"about_ca_topic_score_gemma":0.001029224,"domain_scores_codex":[0.9982607,0.0002055341,0.0003404199,0.0004606724,0.0003087794,0.0004238849],"domain_scores_gemma":[0.9993791,0.0001358913,0.0001077147,0.0001823385,0.00004312632,0.0001518332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008608537,0.002713747,0.002317118,0.0002063966,0.0003004373,0.0005967537,0.001728049,0.271905,0.4130408,0.000580452,0.2706655,0.02733722],"study_design_scores_gemma":[0.01850029,0.01000224,0.0001301476,0.0000421229,0.00009617161,0.000139488,0.00128519,0.1595226,0.1718984,0.00177554,0.6354791,0.001128712],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873378,0.00146133,0.005786768,0.001927967,0.00133035,0.0004459877,0.0001469535,0.00001934364,0.001543469],"genre_scores_gemma":[0.994431,0.0001327759,0.0004348517,0.002463917,0.0004307054,0.0006955091,0.000338772,0.00003355045,0.00103893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3648137,"threshold_uncertainty_score":0.6298231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235381422270307,"score_gpt":0.2948935720375525,"score_spread":0.2825397578148495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}