{"id":"W4280489627","doi":"10.3390/diagnostics12051244","title":"Multi Cancer Early Detection by Using Circulating Tumor DNA—The Galleri Test. Reply to Klein et al. The Promise of Multicancer Early Detection. Comment on “Pons-Belda et al. Can Circulating Tumor DNA Support a Successful Screening Test for Early Cancer Detection? The Grail Paradigm. Diagnostics 2021, 11, 2171”","year":2022,"lang":"en","type":"article","venue":"Diagnostics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Mount Sinai Hospital","funders":"","keywords":"Criticism; Test (biology); Circulating tumor DNA; Constructive; Holy Grail; Cancer; Philosophy; Epistemology; Psychology; Medicine; Biology; Internal medicine; Political science; Computer science; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02304404,0.001709624,0.002311027,0.001924954,0.004524897,0.00499731,0.006738112,0.07674827,0.004626217],"category_scores_gemma":[0.09189433,0.001652345,0.003258238,0.001366236,0.0104331,0.009236988,0.002983833,0.09752271,0.005913588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006761763,"about_ca_system_score_gemma":0.005975035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008915605,"about_ca_topic_score_gemma":0.009013344,"domain_scores_codex":[0.9858859,0.004146245,0.001975366,0.002330533,0.004437154,0.00122488],"domain_scores_gemma":[0.9302005,0.04722939,0.003782289,0.001753473,0.01263113,0.00440328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007282304,0.0000145462,0.0002142392,0.0001188369,0.00002234826,0.0003456272,0.000192671,0.00002908235,0.0001558852,0.001582646,0.993937,0.0033143],"study_design_scores_gemma":[0.0001764985,0.0001542323,0.001646568,0.0008137592,0.0001314012,0.001795829,0.001058308,0.0003485593,0.001220615,0.01023397,0.9821823,0.0002378592],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.00007381438,0.002534823,0.00008734507,0.9650891,0.03187996,0.000007866613,0.00004633905,0.00002504715,0.0002556228],"genre_scores_gemma":[0.0007542832,0.0009424378,0.0001230277,0.9736268,0.02370124,0.00002282465,0.00001590211,0.00001783253,0.0007955953],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.07674827,"threshold_uncertainty_score":0.12187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01992552489980014,"score_gpt":0.2886553917907597,"score_spread":0.2687298668909595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}