{"id":"W4280490423","doi":"10.1017/cjn.2022.60","title":"B-Cell-Directed Therapies: A New Era in Multiple Sclerosis Treatment","year":2022,"lang":"en","type":"review","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alexander S. Onassis Public Benefit Foundation; Hellenic Academic Libraries Link","keywords":"Rituximab; Medicine; Multiple sclerosis; Immunology; B-cell activating factor; B cell; Ocrelizumab; Bruton's tyrosine kinase; Tyrosine kinase; Lymphoma; Internal medicine; Antibody","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009119905,0.0004394508,0.0008944631,0.000952376,0.0003153662,0.00108951,0.0005603779,0.001417563,0.004511686],"category_scores_gemma":[0.0008780714,0.000122612,0.0004218851,0.0006859694,0.0006633536,0.001451369,0.0007529182,0.003266284,0.00141008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008850502,"about_ca_system_score_gemma":0.001329131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001007651,"about_ca_topic_score_gemma":0.002504119,"domain_scores_codex":[0.999647,0.00009526379,0.00003447703,0.00004095568,0.0001415538,0.00004070418],"domain_scores_gemma":[0.9995739,0.0001714773,0.00004930743,0.00001460443,0.0001218691,0.00006882855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000251694,0.0001805019,0.000210141,0.004444439,0.00008085211,0.0003072075,0.0001249374,0.0002378271,0.00414492,0.01191903,0.05757812,0.9205204],"study_design_scores_gemma":[0.0001138463,0.000375107,0.0005871792,0.002231392,0.00007695328,0.0007867835,0.00006343686,0.0001336129,0.0006328824,0.005013507,0.9899703,0.00001486761],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005430123,0.9893962,0.0004201619,0.006383941,0.001030126,0.000008718179,0.00002570669,0.0000284294,0.002163779],"genre_scores_gemma":[0.00455751,0.9858973,0.001087525,0.004278184,0.002196614,0.00002058818,0.00004981957,0.000009266236,0.001903165],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004511686,"threshold_uncertainty_score":0.01509309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1993609216117102,"score_gpt":0.3471740219926229,"score_spread":0.1478131003809128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}