{"id":"W4280490640","doi":"10.21203/rs.3.rs-1628519/v1","title":"TSLP induces platelet mitophagy and promotes thrombosis in Kawasaki disease ","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Kawasaki Disease and Coronary Complications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Canadian Blood Services; University of Toronto","funders":"Guangzhou Institute of Pediatrics, Guangzhou Women and Childrens Medical Center; Basic and Applied Basic Research Foundation of Guangdong Province; Guangzhou Medical University","keywords":"Thymic stromal lymphopoietin; Platelet activation; Downregulation and upregulation; Platelet; Immunology; Medicine; Cytokine; Thrombosis; Flow cytometry; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011099,0.0002830734,0.0002226228,0.0003615332,0.000157191,0.0002442608,0.00007833981,0.0002409871,0.001176057],"category_scores_gemma":[0.0001732051,0.0001128093,0.0002012312,0.0001893403,0.0001592286,0.0001247403,0.0002955849,0.0003317929,0.0001725314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000149815,"about_ca_system_score_gemma":0.00005754038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001631537,"about_ca_topic_score_gemma":0.0001314721,"domain_scores_codex":[0.9998741,0.00003108903,0.00001447405,0.00002463347,0.00002788001,0.0000278537],"domain_scores_gemma":[0.9998968,0.00001539387,0.00004049232,0.000006570161,0.00001603178,0.00002480508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001093647,0.00009363131,0.03477317,0.0002762203,0.00006942558,0.002300518,0.0001404354,0.0001059805,0.9546156,0.0001279445,0.0003604669,0.006043027],"study_design_scores_gemma":[0.0001820779,0.00211622,0.6779965,0.00007478465,0.0002430354,0.01222497,0.0006567848,0.002603194,0.2963724,0.0005535606,0.006947441,0.00002916476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966157,0.002234098,0.0004856614,0.00006064711,0.0000171337,0.00001241998,0.0001254547,0.0000208296,0.0004280257],"genre_scores_gemma":[0.9985857,0.0006570143,0.0002386805,0.00003799062,0.00002059083,0.00001606322,0.0001559756,0.000002129097,0.000285884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001176057,"threshold_uncertainty_score":0.003934324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1196700556023052,"score_gpt":0.4405901683336618,"score_spread":0.3209201127313566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}