{"id":"W4280492129","doi":"10.1073/pnas.2114324119","title":"H3K9 methylation drives resistance to androgen receptor–antagonist therapy in prostate cancer","year":2022,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; Medical Research Council; National Institute for Health and Care Research; U.S. Department of Defense","keywords":"Prostate cancer; Antiandrogens; Cancer research; Antiandrogen; Vorinostat; Gene silencing; Androgen receptor; Epigenetics; Flutamide; Epigenetic therapy; Biology; Cancer; Medicine; Internal medicine; Histone; DNA methylation; Gene expression; Genetics; Histone deacetylase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001096908,0.00007331216,0.00009244704,0.0001418919,0.0002048948,0.00001447756,0.0005778269,0.00004085872,0.0000311796],"category_scores_gemma":[0.0001564007,0.00005993752,0.00004794022,0.0008617213,0.0002054386,0.00001465681,0.0002485379,0.000143218,3.139814e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007124616,"about_ca_system_score_gemma":0.0001059857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001739467,"about_ca_topic_score_gemma":0.00000205959,"domain_scores_codex":[0.9984495,0.00002151374,0.0002098825,0.0002924312,0.0008699244,0.0001567177],"domain_scores_gemma":[0.9995958,0.0000131672,0.0001738054,0.00001270533,0.0001755435,0.00002896915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001545523,0.0000267412,0.000868035,0.00001174046,0.00001187491,5.649063e-9,0.0001693658,0.001362563,0.9941114,0.001542852,0.0010343,0.0007066145],"study_design_scores_gemma":[0.0002449527,0.0001214927,0.002415505,0.00002024141,0.000001611914,0.00000110848,0.0001699217,0.00007453742,0.9823107,0.002788004,0.0117787,0.0000732827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927045,0.001215772,0.000004512386,0.004413824,0.00002912478,0.0004418361,0.0000637053,0.000003443331,0.001123299],"genre_scores_gemma":[0.9979536,0.0003854427,0.0005803821,0.0003151297,0.00003864482,0.0001423551,0.000001209025,0.000006484141,0.0005767565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01180072,"threshold_uncertainty_score":0.2444181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02601174289027504,"score_gpt":0.3300545220281426,"score_spread":0.3040427791378676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}