{"id":"W4280496463","doi":"10.1038/s41419-022-04919-1","title":"Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity","year":2022,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Alberta Bone and Joint Health Institute; University of Calgary","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Aggrecan; Cartilage; Osteoarthritis; Synovial joint; Cell biology; Extracellular matrix; Progenitor cell; Type II collagen; Regeneration (biology); Chemistry; Medicine; Anatomy; Pathology; Biology; Stem cell; Articular cartilage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009268865,0.0001938505,0.0002257801,0.0002377053,0.0001562555,0.0004707174,0.0001492649,0.0001710201,0.0007129438],"category_scores_gemma":[0.00009962689,0.00008887966,0.0001478512,0.0001618489,0.000196048,0.00016269,0.0002970281,0.000410533,0.000319547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002549607,"about_ca_system_score_gemma":0.0002789581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004072,"about_ca_topic_score_gemma":0.0008716854,"domain_scores_codex":[0.9998449,0.00002043563,0.00001176252,0.00002211899,0.00005776291,0.00004292567],"domain_scores_gemma":[0.9999228,0.000005696689,0.00002037974,0.000005125331,0.00001455997,0.00003153449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001775275,0.00002344276,0.0008964823,0.00007465992,0.000004876086,0.0001122638,0.00004301743,0.0000803033,0.9939902,0.0002507762,0.00007010313,0.004276525],"study_design_scores_gemma":[0.00005502851,0.0006426029,0.05344186,0.00003311712,0.00006309801,0.0006607614,0.0003488554,0.003097561,0.9307702,0.0002914489,0.01057961,0.00001575834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869781,0.007206266,0.002704781,0.00008332265,0.00002366385,0.00002208378,0.000196339,0.00007719458,0.002708307],"genre_scores_gemma":[0.995462,0.001540698,0.0006602663,0.00002946306,0.000009880462,0.0000143747,0.0001331647,0.000006148859,0.002144055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001004072,"threshold_uncertainty_score":0.00238502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02175346590046783,"score_gpt":0.2147215258269085,"score_spread":0.1929680599264406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}