{"id":"W4280496533","doi":"10.1016/j.mce.2022.111630","title":"Bisphenol S induces Agrp expression through GPER1 activation and alters transcription factor expression in immortalized hypothalamic neurons: A mechanism distinct from BPA-induced upregulation","year":2022,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Downregulation and upregulation; Endocrinology; Bisphenol S; Internal medicine; Transcription factor; Endocrine disruptor; Biology; Estrogen receptor; Chemistry; Cell biology; Bisphenol; Endocrine system; Medicine; Hormone; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001470576,0.0004333036,0.0002793614,0.0004451238,0.0002277005,0.0003477616,0.000234519,0.0002691821,0.001460378],"category_scores_gemma":[0.0001363224,0.0002444702,0.0005008443,0.0002869214,0.00040986,0.0003764119,0.0002597527,0.0007681666,0.0002605953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004480355,"about_ca_system_score_gemma":0.0003117658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001718804,"about_ca_topic_score_gemma":0.00342001,"domain_scores_codex":[0.9997903,0.00002226196,0.00001654217,0.00004773133,0.00005675072,0.0000664805],"domain_scores_gemma":[0.9998776,0.00002469735,0.00003392823,0.00001866015,0.00001521275,0.0000297703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001720679,0.00001884114,0.0001428065,0.00001318566,0.000005550241,0.0000537767,0.00001919487,0.00002256751,0.9990851,0.00006266176,0.00001891616,0.0003853026],"study_design_scores_gemma":[0.00001207106,0.0001414242,0.008414995,0.000003991216,0.00001573383,0.0001621961,0.00009763367,0.0003412495,0.9896919,0.00008625448,0.001026136,0.000006493389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995464,0.0005924492,0.002093838,0.0001503163,0.00006354002,0.00001421447,0.0005895561,0.00005468724,0.0009773985],"genre_scores_gemma":[0.9893857,0.001260469,0.003123416,0.000128646,0.00002330028,0.00005379688,0.001209241,0.00004536481,0.004769844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001718804,"threshold_uncertainty_score":0.004885435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01430925058532041,"score_gpt":0.2667585443869334,"score_spread":0.252449293801613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}