{"id":"W4280498620","doi":"10.1126/scitranslmed.abj9954","title":"Acute inflammatory response via neutrophil activation protects against the development of chronic pain","year":2022,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":329,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Queen's University; McGill University; McGill University Health Centre","funders":"National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; Università degli Studi di Parma; Canada Excellence Research Chairs, Government of Canada; Medical Research Council; Pfizer Canada; European Commission; Pfizer","keywords":"Medicine; Inflammation; Analgesic; Chronic pain; Immune system; Acute pain; Peripheral; Transcriptome; Immunology; Internal medicine; Anesthesia; Physical therapy; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004496646,0.0001118691,0.0001605218,0.0002459992,0.0006823033,0.000003587452,0.0001925346,0.0000171305,0.0001601586],"category_scores_gemma":[0.0001420552,0.00007129695,0.00003352033,0.000800473,0.0004044868,0.0001013405,0.00002941972,0.0001803258,0.000002828027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002930746,"about_ca_system_score_gemma":0.001592821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003774027,"about_ca_topic_score_gemma":0.000003249089,"domain_scores_codex":[0.9977236,0.0002015271,0.0003293126,0.0002395113,0.001295811,0.0002102689],"domain_scores_gemma":[0.9992366,0.0002152563,0.0001289113,0.0002104783,0.0001198284,0.00008891174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008711706,0.0001151108,0.0005266085,0.00003028523,0.00005385189,0.00001225545,0.003190874,0.0004222945,0.9535052,0.0004214067,0.00002095061,0.04083003],"study_design_scores_gemma":[0.01521286,0.005524858,0.5236911,0.0007760499,0.000188616,0.0001252343,0.002174334,0.03565467,0.3974422,0.004783968,0.01382807,0.0005980906],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692345,0.0001127053,0.01742699,0.01179811,0.000135546,0.001017275,0.000004122823,0.00003155985,0.0002392446],"genre_scores_gemma":[0.9971099,0.000002844712,0.002008451,0.0005100553,0.00006875442,0.0001794676,0.00002589084,0.000008876686,0.00008575067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.556063,"threshold_uncertainty_score":0.5247794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01886904915129972,"score_gpt":0.2800151967479872,"score_spread":0.2611461475966875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}