{"id":"W4280501079","doi":"10.1177/20552173221086662","title":"Fecal microbiota transplantation is safe and tolerable in patients with multiple sclerosis: A pilot randomized controlled trial","year":2022,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal - Experimental Translational and Clinical","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; St Joseph's Health Care; Lawson Health Research Institute; London Health Sciences Centre; Western University","funders":"London Health Sciences Foundation","keywords":"Medicine; Intestinal permeability; Multiple sclerosis; Gut flora; Gastroenterology; Internal medicine; Randomized controlled trial; Transplantation; Feces; Fecal bacteriotherapy; Immunology; Biology; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00201783,0.001313665,0.003505194,0.0004668249,0.0007394961,0.001105554,0.0006968463,0.002233915,0.005285439],"category_scores_gemma":[0.002680491,0.0004947607,0.00224638,0.0005929111,0.001356424,0.001094138,0.0005328679,0.0023851,0.0004859352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006101339,"about_ca_system_score_gemma":0.001245181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007555819,"about_ca_topic_score_gemma":0.001350359,"domain_scores_codex":[0.9990188,0.0005398311,0.00008917526,0.0001507154,0.00006787397,0.0001335309],"domain_scores_gemma":[0.9981704,0.0005493623,0.0004915352,0.0001321942,0.000111227,0.0005452821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.985315,0.004726397,0.0004170224,0.0005014398,0.0007550993,0.0000400733,0.00002490301,0.00007834807,0.000815361,0.00003307061,0.0001983811,0.007094926],"study_design_scores_gemma":[0.9100078,0.08736515,0.001528113,0.00004617803,0.0004451316,0.00002322486,0.00001740083,0.0001546271,0.0001483031,0.00006445042,0.0001918244,0.000007757279],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858123,0.006211468,0.0005473447,0.0009682344,0.0007140219,0.004294874,0.0005045945,0.000107956,0.000839167],"genre_scores_gemma":[0.9884039,0.002504088,0.001180442,0.0008993019,0.0006085143,0.005105009,0.0003512779,0.00001350351,0.000933991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005285439,"threshold_uncertainty_score":0.01768154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04497412016135997,"score_gpt":0.2874829487925395,"score_spread":0.2425088286311795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}