{"id":"W4280501338","doi":"10.34067/kid.0007022021","title":"Inhibitory Antibodies against PCSK9 Reduce Surface CD36 and Mitigate Diet-Induced Renal Lipotoxicity","year":2022,"lang":"en","type":"article","venue":"Kidney360","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Université de Montréal; Montreal Clinical Research Institute; St. Joseph’s Healthcare Hamilton","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"CD36; Endocrinology; PCSK9; Internal medicine; Kidney; Lipotoxicity; Nephrology; LDL receptor; Inflammation; Chemistry; Receptor; Biology; Medicine; Lipoprotein; Cholesterol; Insulin resistance; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009588326,0.0002385296,0.0005176454,0.00008853397,0.0005375157,0.00002404024,0.0001123216,0.00009355839,0.0001006793],"category_scores_gemma":[0.0001515896,0.0002244612,0.0002349097,0.0002678199,0.0001062934,0.00009523083,0.0002651123,0.0006297879,0.00001735127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001701809,"about_ca_system_score_gemma":0.0004155645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002747114,"about_ca_topic_score_gemma":0.000008952498,"domain_scores_codex":[0.9976935,0.0002312318,0.000331656,0.0005226129,0.000758723,0.0004622439],"domain_scores_gemma":[0.9986783,0.00003089578,0.0001011014,0.0006004855,0.00008124037,0.0005080049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008961108,0.0005013229,0.007759864,0.0007708316,0.0007157946,0.0008965114,0.001677577,0.00007064253,0.9291233,0.0003051052,0.03491125,0.02237167],"study_design_scores_gemma":[0.01130974,0.003177597,0.08377156,0.0006707966,0.0006181289,0.001080067,0.003567732,0.0007723892,0.4942719,0.0004419992,0.3986689,0.001649125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890553,0.002143139,0.000008210027,0.003159418,0.0004847563,0.0006998611,0.00010127,0.000143422,0.004204594],"genre_scores_gemma":[0.9950677,0.0002818237,0.000418945,0.002434554,0.0005686348,0.0000461104,0.0000674475,0.00004769921,0.001067121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4348514,"threshold_uncertainty_score":0.9153262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870795015163298,"score_gpt":0.2600096077153539,"score_spread":0.2413016575637209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}