{"id":"W4280501338","doi":"10.34067/kid.0007022021","title":"Inhibitory Antibodies against PCSK9 Reduce Surface CD36 and Mitigate Diet-Induced Renal Lipotoxicity","year":2022,"lang":"en","type":"article","venue":"Kidney360","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Université de Montréal; Montreal Clinical Research Institute; St. Joseph’s Healthcare Hamilton","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"CD36; Endocrinology; PCSK9; Internal medicine; Kidney; Lipotoxicity; Nephrology; LDL receptor; Inflammation; Chemistry; Receptor; Biology; Medicine; Lipoprotein; Cholesterol; Insulin resistance; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001765636,0.0004788689,0.0005390057,0.0003649632,0.0001844301,0.0003258839,0.0003250597,0.0004249831,0.002022757],"category_scores_gemma":[0.000171693,0.0002239256,0.000391416,0.0002010799,0.0003585976,0.0002358932,0.0002194169,0.001496478,0.0004996294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003795218,"about_ca_system_score_gemma":0.0004158504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007878622,"about_ca_topic_score_gemma":0.001482108,"domain_scores_codex":[0.999763,0.00001736085,0.0000307679,0.00003850479,0.00006480118,0.00008560073],"domain_scores_gemma":[0.9998083,0.00001695421,0.00005783267,0.00001756585,0.00002320883,0.00007622056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001225927,0.0003113934,0.0002503344,0.00008587683,0.00001949895,0.00003132934,0.00001382406,0.0001504405,0.9943759,0.00009602498,0.0001584223,0.003281083],"study_design_scores_gemma":[0.0001906902,0.00220843,0.003389591,0.0000103085,0.00004167407,0.0002099934,0.00003023217,0.00102345,0.9907836,0.00005543292,0.002049269,0.000007240984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942468,0.001485428,0.002068767,0.0002618549,0.00009917105,0.00006771881,0.0004644427,0.0002010281,0.001104711],"genre_scores_gemma":[0.9906686,0.001558932,0.003260028,0.0001734657,0.00003398765,0.00009000134,0.0007261109,0.00004187919,0.003446973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002022757,"threshold_uncertainty_score":0.006766737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870795015163298,"score_gpt":0.2600096077153539,"score_spread":0.2413016575637209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}