{"id":"W4280503920","doi":"10.1038/s41598-022-12528-3","title":"Cancer genomic profiling identified dihydropyrimidine dehydrogenase deficiency in bladder cancer promotes sensitivity to gemcitabine","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Research Promotion Foundation","keywords":"Gemcitabine; DPYD; Bladder cancer; Dihydropyrimidine dehydrogenase; Cancer research; Exome sequencing; Cancer; Biology; Oncology; Internal medicine; Medicine; Gene; Mutation; Genetics; Pharmacogenetics; Thymidylate synthase; Fluorouracil; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008414829,0.0001180965,0.0002006545,0.0005059634,0.0001251266,0.0002875367,0.00008098478,0.0002096917,0.0006340106],"category_scores_gemma":[0.0003227013,0.00009456482,0.0001515217,0.0005518682,0.0000864411,0.00007242936,0.0001702463,0.0001512909,0.00009262688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001625315,"about_ca_system_score_gemma":0.0001150422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006760993,"about_ca_topic_score_gemma":0.001015449,"domain_scores_codex":[0.9999053,0.00001398367,0.000008414133,0.00002757315,0.00002632898,0.00001824112],"domain_scores_gemma":[0.9998894,0.00002617457,0.00003964776,0.000008898556,0.00001783384,0.00001792292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001166829,0.00005590932,0.2592687,0.0001556505,0.0001007871,0.001390287,0.0001826903,0.0004357001,0.7153982,0.0001061029,0.0003262134,0.02141299],"study_design_scores_gemma":[0.00001200111,0.000240249,0.9195869,0.00002102077,0.0001448911,0.00334737,0.0001633644,0.001637459,0.07222091,0.0001541853,0.002463785,0.000007879226],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977596,0.0008794299,0.0004683871,0.00004811569,0.000004295738,0.000008406892,0.0005145671,0.00001550769,0.0003017196],"genre_scores_gemma":[0.9980291,0.0004308911,0.000553287,0.00004075158,0.000003278996,0.000007979149,0.0006513604,0.000003840849,0.0002794946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006760993,"threshold_uncertainty_score":0.002120972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02390642500420592,"score_gpt":0.3012624190220083,"score_spread":0.2773559940178024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}