{"id":"W4280509090","doi":"10.1038/s41467-022-30310-x","title":"A truncated anti-CRISPR protein prevents spacer acquisition but not interference","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"French Infrastructure for Integrated Structural Biology; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Agence Nationale de la Recherche","keywords":"CRISPR; Cas9; CRISPR interference; Biology; Gene; DNA; Acquired immune system; Genetics; Nucleic acid; Mutant; Computational biology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001437022,0.0004441111,0.0003847019,0.0001781051,0.0001403086,0.0003292575,0.0004517098,0.0004301376,0.001627862],"category_scores_gemma":[0.0001680127,0.0001890958,0.0003281685,0.0001430825,0.0003790805,0.0001253532,0.000228109,0.0008009659,0.0007860411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003024533,"about_ca_system_score_gemma":0.0003357049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006319841,"about_ca_topic_score_gemma":0.0007302848,"domain_scores_codex":[0.9997265,0.00003601943,0.00004368688,0.00005552779,0.00009635845,0.0000418184],"domain_scores_gemma":[0.9996717,0.00006420954,0.00009540834,0.00006305787,0.00002926736,0.00007631007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002965261,0.00001804579,0.00003796295,0.00001322179,0.000002829675,0.00002797859,0.000002796911,0.00003483407,0.9994661,0.00007501969,0.00001719195,0.0002743458],"study_design_scores_gemma":[0.000006860912,0.0001147179,0.0008443175,0.000002324644,0.000006162834,0.0001985338,0.000004336289,0.0005684154,0.9966195,0.00002073101,0.001610529,0.000003564095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881251,0.0004224026,0.007946814,0.0001198029,0.0001093246,0.00003618596,0.0005728591,0.0002467288,0.002420745],"genre_scores_gemma":[0.9890634,0.0002264349,0.005144295,0.00008472631,0.00001407989,0.00002836201,0.001027206,0.00007987648,0.004331652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001627862,"threshold_uncertainty_score":0.005445719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178180665591174,"score_gpt":0.3167913688626129,"score_spread":0.3050095622067012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}