{"id":"W4280509090","doi":"10.1038/s41467-022-30310-x","title":"A truncated anti-CRISPR protein prevents spacer acquisition but not interference","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"French Infrastructure for Integrated Structural Biology; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Agence Nationale de la Recherche","keywords":"CRISPR; Cas9; CRISPR interference; Biology; Gene; DNA; Acquired immune system; Genetics; Nucleic acid; Mutant; Computational biology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001394148,0.0001037116,0.00008414596,0.00004871128,0.0002597062,0.00001780316,0.0006484034,0.0001170758,0.00005392558],"category_scores_gemma":[0.00004533986,0.0001146734,0.00005951603,0.0001474582,0.00003900188,0.000003173449,0.0007903131,0.0004941388,0.000005593724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002677704,"about_ca_system_score_gemma":0.00004360843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001419684,"about_ca_topic_score_gemma":0.00003259292,"domain_scores_codex":[0.9993038,0.0001102288,0.0001365382,0.0001953285,0.0001133681,0.0001407519],"domain_scores_gemma":[0.9986991,0.00001069532,0.00005269268,0.001136667,0.00006020714,0.00004069443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002445628,0.0001077066,0.0003530924,0.000007222024,0.0000328796,5.374495e-7,0.00007358872,0.0002462351,0.9957977,0.0003497224,0.002344556,0.0006623063],"study_design_scores_gemma":[0.0006675009,0.0002477332,0.01196794,0.00002577678,0.00003661789,0.00003427641,0.0003012806,0.001429434,0.8024296,0.00008559508,0.1823826,0.0003916427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858614,0.005201684,0.004712498,0.002112905,0.0002049473,0.0005432132,0.0001367119,0.00005389243,0.001172781],"genre_scores_gemma":[0.9956864,0.0001366497,0.002204699,0.0003077532,0.00004339556,0.0002140703,0.0005555999,0.0000183339,0.0008331146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1933681,"threshold_uncertainty_score":0.4676244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178180665591174,"score_gpt":0.3167913688626129,"score_spread":0.3050095622067012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}