{"id":"W4280511499","doi":"10.1038/s41589-022-01025-3","title":"Putting introns on retainer","year":2022,"lang":"en","type":"letter","venue":"Nature Chemical Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"","keywords":"Triple-negative breast cancer; Methyltransferase; Biology; Mimicry; Intron; Cancer research; Computational biology; Breast cancer; Cancer; Genetics; Gene; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0002127405,0.0003487949,0.0003528946,0.0001006197,0.0001046142,0.00001906591,0.0007207611,0.003613062,0.0004088519],"category_scores_gemma":[0.0007814275,0.000293992,0.0002470147,0.0001204199,0.0001645265,9.932772e-7,0.0005306355,0.006690783,0.00003291341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007569981,"about_ca_system_score_gemma":0.0001071376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006939664,"about_ca_topic_score_gemma":8.022731e-7,"domain_scores_codex":[0.9977071,0.0001820797,0.0002431729,0.0009098044,0.0002242467,0.0007335569],"domain_scores_gemma":[0.9989725,0.0001128288,0.0001132783,0.0006408895,0.00007217072,0.00008829981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005364425,0.00001110214,0.00003269167,0.00001596295,0.00005595995,0.00004092319,0.000001035128,3.707605e-7,0.4358869,0.00004625196,0.5624308,0.001424403],"study_design_scores_gemma":[0.0002452801,0.0003308134,0.000002533471,0.000009127374,0.00001199525,0.0000328253,0.000002211151,0.000005191491,0.1058349,0.0002484838,0.8930214,0.0002552454],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1060097,0.004167717,0.0000373406,0.8758999,0.001248399,0.0005675799,0.0004336865,0.0000861216,0.01154957],"genre_scores_gemma":[0.04176331,0.0001814376,0.0005186536,0.920512,0.01234028,0.0001284917,0.01398061,0.0001122125,0.01046304],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.3305906,"threshold_uncertainty_score":0.9999512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00767926483129636,"score_gpt":0.2802483164246372,"score_spread":0.2725690515933408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}