{"id":"W4280513337","doi":"10.1016/j.matbio.2022.05.004","title":"Stiffness-responsive feedback autoregulation of DDR1 expression is mediated by a DDR1-YAP/TAZ axis","year":2022,"lang":"en","type":"article","venue":"Matrix Biology","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ted Rogers Centre for Heart Research; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"DDR1; Discoidin domain; Cell biology; Gene knockdown; Transcription factor; Chemistry; Receptor tyrosine kinase; Signal transduction; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002311663,0.0006273626,0.0003160474,0.0003995392,0.0004154055,0.0006308814,0.0003403638,0.0002736703,0.002988606],"category_scores_gemma":[0.0002857061,0.000343062,0.0004047353,0.0001615611,0.0004307673,0.0005244804,0.000697046,0.0007481755,0.001018372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001001099,"about_ca_system_score_gemma":0.0003955371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009366411,"about_ca_topic_score_gemma":0.002722713,"domain_scores_codex":[0.99966,0.0000288647,0.00002758908,0.0001140413,0.00008729762,0.00008209531],"domain_scores_gemma":[0.9996963,0.00003098512,0.0001181352,0.00003423711,0.00004397205,0.00007650701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005569833,0.000006788999,0.000150883,0.00001647286,0.000002159972,0.00002849183,0.000008968037,0.00004328815,0.9989416,0.0001293868,0.00005604761,0.0005602437],"study_design_scores_gemma":[0.000009988673,0.00003409839,0.008573824,0.000003641747,0.000005824153,0.00009854002,0.00003417698,0.001296705,0.9883199,0.00007448157,0.001539907,0.000008938287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705748,0.002918766,0.01749488,0.0006710697,0.0001712879,0.000057638,0.001449128,0.001009991,0.00565247],"genre_scores_gemma":[0.9881132,0.0004545068,0.003780805,0.0001044255,0.00002185831,0.00004669706,0.0008424053,0.00009826363,0.006537681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002988606,"threshold_uncertainty_score":0.009997904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008442160862153648,"score_gpt":0.2609163880570344,"score_spread":0.2524742271948808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}