{"id":"W4280514570","doi":"10.1111/all.15376","title":"Airway remodelling rather than cellular infiltration characterizes both type2 cytokine biomarker‐high and ‐low severe asthma","year":2022,"lang":"en","type":"article","venue":"Allergy","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Manchester Biomedical Research Centre; National Institute for Health and Care Research; University Hospitals of Leicester NHS Trust; NIHR Leicester Biomedical Research Centre; Genentech; Medical Research Council Canada; Wellcome Trust","keywords":"Biomarker; Asthma; Medicine; Sputum; Eosinophil; Immunology; Eosinophilic; Inflammation; Exhaled breath condensate; Airway; Periostin; Eosinophil cationic protein; Pathology; Biology; Extracellular matrix","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001196872,0.0001609796,0.0002136558,0.00008938149,0.0002270223,0.00002191123,0.0000704801,0.00005667106,0.001288271],"category_scores_gemma":[0.00001312575,0.0001405421,0.00007122107,0.0001405889,0.00004737361,0.00009207216,0.00007500529,0.0001381779,0.00001431711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003553846,"about_ca_system_score_gemma":0.00009366326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004200017,"about_ca_topic_score_gemma":0.00001028435,"domain_scores_codex":[0.9989581,0.00008635152,0.0002015448,0.0002888947,0.0002603352,0.0002047706],"domain_scores_gemma":[0.9994727,0.00002573308,0.00008674167,0.0002411872,0.00003564368,0.0001380307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002660572,0.001048654,0.008306942,0.0002885911,0.0006176679,0.0008102077,0.00126948,0.001001743,0.9123621,0.001266904,0.007963706,0.06240346],"study_design_scores_gemma":[0.005322089,0.001793815,0.1276441,0.0001783133,0.0001153813,0.0003096532,0.0008811485,0.01333206,0.01564808,0.0002597642,0.8335637,0.0009519744],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966439,0.0009346618,0.0003075076,0.0004811951,0.0001842962,0.0002090867,0.0000623484,0.00007530477,0.001101717],"genre_scores_gemma":[0.9964097,0.0001271301,0.000121776,0.0007314343,0.0002196823,0.0000298323,0.0002925667,0.00003866678,0.002029243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.896714,"threshold_uncertainty_score":0.9996247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01152536999038921,"score_gpt":0.2206202290038671,"score_spread":0.2090948590134779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}