{"id":"W4280514570","doi":"10.1111/all.15376","title":"Airway remodelling rather than cellular infiltration characterizes both type2 cytokine biomarker‐high and ‐low severe asthma","year":2022,"lang":"en","type":"article","venue":"Allergy","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Manchester Biomedical Research Centre; National Institute for Health and Care Research; University Hospitals of Leicester NHS Trust; NIHR Leicester Biomedical Research Centre; Genentech; Medical Research Council Canada; Wellcome Trust","keywords":"Biomarker; Asthma; Medicine; Sputum; Eosinophil; Immunology; Eosinophilic; Inflammation; Exhaled breath condensate; Airway; Periostin; Eosinophil cationic protein; Pathology; Biology; Extracellular matrix","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003204256,0.0003131772,0.000382623,0.0004653488,0.0002503991,0.0005921893,0.0001900476,0.0005592875,0.0022777],"category_scores_gemma":[0.0005145834,0.0001992247,0.0002460714,0.0002238025,0.0005177853,0.0003254095,0.0003936936,0.000555152,0.0003232679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001675337,"about_ca_system_score_gemma":0.0001139221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002566634,"about_ca_topic_score_gemma":0.0004972236,"domain_scores_codex":[0.9997,0.00005657852,0.00003406014,0.000080714,0.00005825466,0.00007039437],"domain_scores_gemma":[0.9993941,0.00008883377,0.0002350076,0.00004750719,0.00004087502,0.0001936206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002196308,0.0002034122,0.7477888,0.0001699049,0.00008013364,0.002361859,0.0002535004,0.00007636422,0.2407065,0.0001611196,0.0003200864,0.005681979],"study_design_scores_gemma":[0.00002497871,0.000681326,0.9867353,0.00001705634,0.00003968396,0.005707532,0.0003336982,0.0002010963,0.00561759,0.0001407549,0.0004947585,0.000006182818],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987504,0.0004401829,0.0002193035,0.0000342778,0.000007068566,0.00001791521,0.00008814007,0.000007983097,0.0004346799],"genre_scores_gemma":[0.9993823,0.0000673449,0.0001701893,0.00004770639,0.00001839287,0.00001103947,0.0001474475,0.000002556093,0.000153123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0022777,"threshold_uncertainty_score":0.007619679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01152536999038921,"score_gpt":0.2206202290038671,"score_spread":0.2090948590134779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}