{"id":"W4280517337","doi":"10.1002/cbic.202200140","title":"Identification of Genes Essential for Sulfamate and Fluorine Incorporation During Nucleocidin Biosynthesis","year":2022,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Biosynthesis; Biochemistry; Biology; Streptomyces; Gene; Enzyme; Acetyltransferase; Acetylation; Chemistry; Stereochemistry; Genetics; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002274407,0.00008923166,0.0001819545,0.00007883336,0.0001545539,0.00001178728,0.00005821076,0.00003887913,0.00007433014],"category_scores_gemma":[0.0001007854,0.00008394224,0.00006070667,0.0001514586,0.00004738968,0.00004667245,0.00007890703,0.00005575462,0.000001220138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003810993,"about_ca_system_score_gemma":0.00002355971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009222391,"about_ca_topic_score_gemma":7.359312e-7,"domain_scores_codex":[0.9992512,0.00001399056,0.0002637534,0.0002436556,0.0001194194,0.0001079495],"domain_scores_gemma":[0.9995002,0.00002280504,0.0001759877,0.0001741116,0.00009175734,0.00003513647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002483547,0.00007656423,0.0003077504,0.0003568579,0.00003505654,0.000001024471,0.00007282485,9.160228e-7,0.9959186,0.00008285883,0.0002201508,0.002679],"study_design_scores_gemma":[0.0004827291,0.000051864,0.001984841,0.00001459978,0.000088607,0.00002248853,0.0001239537,0.00008783218,0.9964852,0.00005438149,0.000514506,0.0000889344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977064,0.0004974695,0.00001849886,0.001193127,0.0001076341,0.0003699206,0.00005871188,0.00002810658,0.00002018296],"genre_scores_gemma":[0.9986985,0.00007530063,0.0003971405,0.00002455393,0.0001543407,0.00001038431,0.00006660223,0.00001611152,0.0005571014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002590066,"threshold_uncertainty_score":0.3423065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00933673874607292,"score_gpt":0.23079970349807,"score_spread":0.2214629647519971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}