{"id":"W4280518096","doi":"10.1016/j.ejcb.2022.151237","title":"MeCP2 and transcriptional control of eukaryotic gene expression","year":2022,"lang":"en","type":"article","venue":"European Journal of Cell Biology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Chromatin; Epigenetics; Regulation of gene expression; ChIA-PET; Chromatin remodeling; Enhancer; Genetics; MECP2; Gene expression; Gene; Cell biology; Histone; Transcriptional regulation; DNA methylation; Epigenetics of physical exercise; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000337218,0.00007936064,0.0001244983,0.00005060957,0.00006040178,0.000003024509,0.0001624047,0.00001599793,0.00006235233],"category_scores_gemma":[0.00001151915,0.00007032986,0.00006829303,0.00003041864,0.0000660827,0.000001442508,0.0000819762,0.0000975256,8.609784e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003361257,"about_ca_system_score_gemma":0.00003442355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":3.447661e-7,"about_ca_topic_score_gemma":1.439086e-7,"domain_scores_codex":[0.9990358,0.0003794288,0.0002841885,0.0001218372,0.0000762651,0.0001024519],"domain_scores_gemma":[0.9996217,0.000008376193,0.0001965612,0.00007712984,0.00004397424,0.00005227179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001912401,0.00006118252,0.001223606,0.000005224465,0.00002024014,0.000008607355,0.0000568892,0.0002249631,0.9972157,0.00002976107,0.000186313,0.0007762092],"study_design_scores_gemma":[0.003373304,0.00333869,0.06543583,0.000006177261,0.00003349796,0.0002110132,0.0001641655,0.0000187561,0.8838457,0.00008113399,0.04330929,0.0001824428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992191,0.00354865,0.002756431,0.00009497687,0.000205764,0.00004782651,0.00003136564,0.000001077949,0.00112292],"genre_scores_gemma":[0.9981434,0.0004543227,0.001013423,0.000241128,0.00003023894,6.566978e-7,0.00002171061,0.00001291744,0.00008217309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1133701,"threshold_uncertainty_score":0.2867969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007119741144267814,"score_gpt":0.1914770752216877,"score_spread":0.1843573340774199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}