{"id":"W4280518301","doi":"10.1016/j.ymthe.2022.05.013","title":"Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"","keywords":"cccDNA; Virology; Nuclease; Hepatitis B virus; HBsAg; Biology; In vivo; Hepatitis B; Circular DNA; Virus; Genetics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004839687,0.0003143791,0.000427968,0.0002140899,0.0004499734,0.00004630969,0.0003051505,0.00004339882,0.001111766],"category_scores_gemma":[0.00004368139,0.0002379528,0.0001107461,0.0008442157,0.000124224,0.00005895274,0.000175744,0.0004673642,0.0000681975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004263331,"about_ca_system_score_gemma":0.0001131981,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01821823,"about_ca_topic_score_gemma":0.003814271,"domain_scores_codex":[0.9974551,0.0002819598,0.0003783918,0.0005398588,0.0007659356,0.0005787927],"domain_scores_gemma":[0.998987,0.00005510155,0.0001020324,0.0005931763,0.00010649,0.0001562247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001344647,0.0006973806,0.2662177,0.00004128729,0.0003636725,0.01025899,0.01218245,0.001810804,0.6602972,0.001096528,0.008774206,0.03691509],"study_design_scores_gemma":[0.008233983,0.006337942,0.1587688,0.0003327999,0.0001016867,0.0004763873,0.001053097,0.001867595,0.1817269,0.000700232,0.6386774,0.001723136],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876542,0.002834075,0.0005843472,0.006128243,0.0001476057,0.001385536,0.00008426804,0.0001049789,0.001076743],"genre_scores_gemma":[0.983817,0.004187776,0.001162515,0.009576431,0.00007198404,0.0008114654,0.00002055601,0.0001032624,0.0002489962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6299032,"threshold_uncertainty_score":0.9998013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02215506840929964,"score_gpt":0.2594389097869557,"score_spread":0.237283841377656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}