{"id":"W4280518301","doi":"10.1016/j.ymthe.2022.05.013","title":"Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"","keywords":"cccDNA; Virology; Nuclease; Hepatitis B virus; HBsAg; Biology; In vivo; Hepatitis B; Circular DNA; Virus; Genetics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000243984,0.0003169251,0.0001674819,0.0001671839,0.0001001821,0.0002272658,0.0001491078,0.0003169315,0.0009526337],"category_scores_gemma":[0.0001222108,0.0001454372,0.0001775048,0.00008054909,0.0002412795,0.0001697557,0.000167941,0.0004098948,0.0003086098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001372261,"about_ca_system_score_gemma":0.0002806361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004987928,"about_ca_topic_score_gemma":0.0006366622,"domain_scores_codex":[0.9998518,0.00002735641,0.00001150617,0.00004521122,0.00004256983,0.00002153071],"domain_scores_gemma":[0.9998975,0.00001895924,0.00003138836,0.00001472879,0.00001388046,0.00002364888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003072905,0.00001347649,0.00002660276,0.00001657898,0.000001817467,0.000009849332,0.000007933845,0.00003102588,0.9987484,0.00007189331,0.00001215832,0.001029504],"study_design_scores_gemma":[0.00001686292,0.0006410331,0.0004806153,0.000004661673,0.000009997137,0.0001975005,0.000005832291,0.000630719,0.9954295,0.00003606451,0.002544143,0.000003087152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9468453,0.003311275,0.04494925,0.00022476,0.00008326018,0.0002263835,0.0002995873,0.0004864355,0.003573681],"genre_scores_gemma":[0.9634403,0.00169992,0.02783524,0.00009682833,0.0000207113,0.0001378689,0.0004165883,0.00007389601,0.006278624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009526337,"threshold_uncertainty_score":0.003186882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02215506840929964,"score_gpt":0.2594389097869557,"score_spread":0.237283841377656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}