{"id":"W4280518675","doi":"10.1164/rccm.202204-0730ed","title":"How Should the Effects of CFTR Modulator Therapy on Cystic Fibrosis Lung Disease Be Monitored?","year":2022,"lang":"en","type":"letter","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Cystic fibrosis; Lung disease; Lung; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003974527,0.0004727505,0.00162279,0.0005848884,0.002213474,0.002589206,0.001201178,0.03515327,0.003147117],"category_scores_gemma":[0.03461524,0.0003511551,0.001318128,0.0004655105,0.002170987,0.003636514,0.0009176177,0.02889062,0.002524485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002965495,"about_ca_system_score_gemma":0.003035778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003068241,"about_ca_topic_score_gemma":0.004890722,"domain_scores_codex":[0.9963453,0.00128998,0.0006035654,0.0003036273,0.001116984,0.0003405601],"domain_scores_gemma":[0.9841015,0.008931044,0.00106606,0.0004763373,0.002612887,0.002812127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004877839,0.0003059165,0.009392244,0.0001781905,0.0001128287,0.01184099,0.0002213681,0.0003657715,0.001183384,0.009198011,0.8883232,0.07839038],"study_design_scores_gemma":[0.0006520794,0.0006556193,0.008791171,0.001016494,0.0002072259,0.013907,0.0008176077,0.001821378,0.0009089846,0.03657062,0.9344986,0.000153231],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.000879654,0.001690709,0.00016769,0.9866642,0.008443257,0.000007337688,0.00002231532,0.00001684461,0.002108053],"genre_scores_gemma":[0.01166283,0.002864707,0.0008022559,0.9200701,0.06173526,0.0000366019,0.00003486973,0.00001603988,0.002777397],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03515327,"threshold_uncertainty_score":0.02151626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02285568086662253,"score_gpt":0.3379568428406701,"score_spread":0.3151011619740476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}