{"id":"W4280518749","doi":"10.1016/j.ejca.2022.04.016","title":"Olaparib tolerability and common adverse-event management in patients with metastatic castration-resistant prostate cancer: Further analyses from the PROfound study","year":2022,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; University of Alberta","funders":"National Cancer Institute; Foundation Medicine; Eisai; Merck Sharp and Dohme; Ipsen; Astellas Pharma; Sanofi; Chugai Pharmaceutical; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Prostate cancer; Tolerability; Olaparib; Medicine; Adverse effect; Oncology; Internal medicine; Cancer; Gynecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002680678,0.0002750456,0.0006203371,0.0002232445,0.0001251907,0.0004845645,0.0002259601,0.000193323,0.001323171],"category_scores_gemma":[0.001817371,0.00009138048,0.00130525,0.0002996121,0.0001758161,0.0002709471,0.0004113186,0.0005517395,0.0001546111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002854485,"about_ca_system_score_gemma":0.0003801314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002214523,"about_ca_topic_score_gemma":0.0004494375,"domain_scores_codex":[0.9991733,0.0004259341,0.0000718365,0.00007187096,0.000191196,0.00006579896],"domain_scores_gemma":[0.9978387,0.0007507224,0.0006480139,0.0001739403,0.0002799292,0.000308769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2222931,0.006709905,0.5404431,0.001274976,0.005460772,0.0007806415,0.0006071496,0.004463308,0.03153749,0.0002664671,0.002540804,0.1836222],"study_design_scores_gemma":[0.01320945,0.1459848,0.8250716,0.00006942341,0.002491745,0.001287589,0.0002012242,0.001784002,0.003885772,0.0002103788,0.005746282,0.00005781186],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968581,0.001117944,0.0002521006,0.0000491088,0.000005364601,0.0001948209,0.0006314463,0.000009300466,0.0008818606],"genre_scores_gemma":[0.9977016,0.0003052876,0.0003330397,0.0001336402,0.00002793013,0.0001007701,0.001144947,0.000003821393,0.0002488927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002680678,"threshold_uncertainty_score":0.01417691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04573720873806924,"score_gpt":0.3604040520670452,"score_spread":0.3146668433289759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}