{"id":"W4280519121","doi":"10.1093/hmg/ddac104","title":"Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways","year":2022,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Bundesministerium für Bildung und Forschung; Agence Nationale de la Recherche; Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; Canada's Michael Smith Genome Sciences Centre","keywords":"Biology; Epigenetics; DNA methylation; Epigenomics; Epigenome; Alpha-synuclein; Genetics; Parkinson's disease; Gene; Gene expression; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007478987,0.0001662127,0.0001530902,0.000205134,0.00008898304,0.0001575878,0.00006915606,0.00013678,0.0006463141],"category_scores_gemma":[0.00008523353,0.0001027947,0.000154742,0.0001237354,0.000115545,0.00006104697,0.0001735893,0.0001967422,0.00008613255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000166197,"about_ca_system_score_gemma":0.0001175335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007978357,"about_ca_topic_score_gemma":0.001970722,"domain_scores_codex":[0.9999263,0.00001203631,0.000005743218,0.00002633478,0.00001615456,0.00001337808],"domain_scores_gemma":[0.9999354,0.000009293629,0.00002604927,0.000007477518,0.000008140171,0.00001366339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001436383,0.00001342504,0.003277949,0.00001532606,0.00001903387,0.00006046801,0.00001776627,0.00007560794,0.9950864,0.00003203024,0.00003139825,0.001226977],"study_design_scores_gemma":[0.00002246709,0.0004850285,0.3568581,0.00001178511,0.00008137154,0.0006758446,0.0001139759,0.002192637,0.6375911,0.0002169688,0.001740248,0.00001043693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978778,0.0004586763,0.0009473393,0.00003113699,0.000006804444,0.000005247301,0.0002836228,0.0000314912,0.0003579648],"genre_scores_gemma":[0.9982089,0.0002641946,0.0004386442,0.00002813494,0.000001766008,0.000009046312,0.0003032974,0.000005707658,0.0007402591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007978357,"threshold_uncertainty_score":0.002162158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02242585888679639,"score_gpt":0.2557596692055777,"score_spread":0.2333338103187814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}