{"id":"W4280519400","doi":"10.1111/jne.13165","title":"Corticotroph isolation from <scp> <i>Pomc‐</i> eGFP </scp> mice reveals sustained transcriptional dysregulation characterising a mouse model of glucocorticoid‐induced suppression of the <scp>hypothalamus–pituitary–adrenal</scp> axis","year":2022,"lang":"en","type":"article","venue":"Journal of Neuroendocrinology","topic":"Adrenal Hormones and Disorders","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Medical Research Council Canada; International Seafood Sustainability Foundation; Wellcome Trust","keywords":"Internal medicine; Endocrinology; Glucocorticoid; Dexamethasone; Hypothalamic–pituitary–adrenal axis; Hypothalamus; Cholesterol side-chain cleavage enzyme; Corticosterone; Proopiomelanocortin; Adrenocorticotropic hormone; Biology; Medicine; Chemistry; Hormone; Metabolism; Cytochrome P450","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001250214,0.0003233203,0.0009230316,0.000419233,0.0002038395,0.00001492376,0.0003987105,0.00009660063,0.00003421528],"category_scores_gemma":[0.0006422024,0.0002625441,0.0005426777,0.0003995686,0.0001473851,0.0003218782,0.0001863314,0.0008543622,0.000001508278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001711812,"about_ca_system_score_gemma":0.0003936933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006778652,"about_ca_topic_score_gemma":0.000004351948,"domain_scores_codex":[0.9960727,0.0004225628,0.001661494,0.0003663943,0.0009594149,0.0005174177],"domain_scores_gemma":[0.9962344,0.0005751913,0.002030098,0.0004524333,0.0005462182,0.0001617279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004618849,0.0004981589,0.01334227,0.00008685442,0.0001862885,0.00009501518,0.0009529304,0.01145945,0.9717156,0.0002278217,0.000576898,0.0003968094],"study_design_scores_gemma":[0.01221283,0.004564337,0.6672964,0.0002265598,0.001385942,0.002856876,0.005561878,0.05110909,0.2514254,0.002436347,0.000764204,0.0001601691],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953524,0.0005979827,0.001460677,0.001148063,0.0005749116,0.0006044196,0.0001410405,0.00002225756,0.00009826751],"genre_scores_gemma":[0.9978497,0.0002905698,0.0004849787,0.0006071417,0.0001483371,0.00001328752,0.0000558114,0.0000585717,0.0004916136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7202902,"threshold_uncertainty_score":0.9999827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02185119123606725,"score_gpt":0.2419370877319184,"score_spread":0.2200858964958511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}