{"id":"W4280520268","doi":"10.3390/v14051029","title":"Understanding the Driving Forces That Trigger Mutations in SARS-CoV-2: Mutational Energetics and the Role of Arginine Blockers in COVID-19 Therapy","year":2022,"lang":"en","type":"article","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Coronavirus disease 2019 (COVID-19); Energetics; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Sars virus; Arginine; Virology; Mutation; Medicine; Biology; Genetics; Infectious disease (medical specialty); Disease; Gene; Internal medicine; Ecology; Amino acid; Outbreak","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009812657,0.0001173475,0.0002288121,0.0003385624,0.0002650164,0.00003672888,0.0001760819,0.00003672933,0.00002538945],"category_scores_gemma":[0.0003664845,0.00007337642,0.00006272876,0.0006357309,0.0004160952,0.00009192514,0.00009293212,0.0002895596,9.648263e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002384299,"about_ca_system_score_gemma":0.0004088185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001058217,"about_ca_topic_score_gemma":0.0007389945,"domain_scores_codex":[0.9985171,0.0002784608,0.000270379,0.0001970272,0.0005144986,0.0002225392],"domain_scores_gemma":[0.9978854,0.001787945,0.00009660608,0.0001856705,0.00002566301,0.00001869835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003005056,0.0004327735,0.7541591,0.00007046496,0.0002407145,0.00009459067,0.03416239,0.001058655,0.1791052,0.02533869,0.0004139775,0.001918394],"study_design_scores_gemma":[0.03362201,0.0007177651,0.02001217,0.0001836942,0.0001376424,0.0001720283,0.1384359,0.02852216,0.4996776,0.08914295,0.1887601,0.0006159918],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928696,0.002564689,0.0002495089,0.00334276,0.00004459893,0.0005127683,0.00001458155,0.0000190207,0.0003825312],"genre_scores_gemma":[0.9717821,0.00008288262,0.00003798729,0.02788489,0.00002753288,0.0001585558,0.00000349341,0.00001719641,0.000005335703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.734147,"threshold_uncertainty_score":0.2992204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1299783513498627,"score_gpt":0.3735252027456508,"score_spread":0.2435468513957881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}