{"id":"W4280520268","doi":"10.3390/v14051029","title":"Understanding the Driving Forces That Trigger Mutations in SARS-CoV-2: Mutational Energetics and the Role of Arginine Blockers in COVID-19 Therapy","year":2022,"lang":"en","type":"article","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Coronavirus disease 2019 (COVID-19); Energetics; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Sars virus; Arginine; Virology; Mutation; Medicine; Biology; Genetics; Infectious disease (medical specialty); Disease; Gene; Internal medicine; Ecology; Amino acid; Outbreak","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002839868,0.0003623531,0.0004696487,0.000224786,0.0001828193,0.0005519905,0.0003323035,0.0004280185,0.00166469],"category_scores_gemma":[0.0003866717,0.00018346,0.0002622688,0.0001217464,0.0002573799,0.0007503476,0.0002625172,0.0005431773,0.0003363377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005216077,"about_ca_system_score_gemma":0.0003320755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007961725,"about_ca_topic_score_gemma":0.0008672159,"domain_scores_codex":[0.9999235,0.00001454521,0.000003643283,0.0000128503,0.00002763317,0.00001778629],"domain_scores_gemma":[0.9999449,0.00002157354,0.00001415901,0.000002428664,0.000008610396,0.000008288833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001455519,0.0007078967,0.01630077,0.001089321,0.000133096,0.001127789,0.0001800962,0.3505671,0.4620851,0.02500414,0.002212746,0.1391365],"study_design_scores_gemma":[0.0001661445,0.001553876,0.0153391,0.0002295725,0.0001494059,0.000882441,0.0003950466,0.8048718,0.1329488,0.02897319,0.01438776,0.0001029087],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9075028,0.0515305,0.02648478,0.00287325,0.0001454255,0.00007206923,0.0002610208,0.0002074028,0.01092273],"genre_scores_gemma":[0.9844403,0.01052152,0.003681487,0.000145361,0.0000417177,0.00002473555,0.00009227432,0.00002937072,0.001023161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00166469,"threshold_uncertainty_score":0.005568981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1299783513498627,"score_gpt":0.3735252027456508,"score_spread":0.2435468513957881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}