{"id":"W4280521018","doi":"10.7554/elife.78463","title":"Structure of the IL-27 quaternary receptor signaling complex","year":2022,"lang":"en","type":"article","venue":"eLife","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Glycoprotein 130; Cell biology; Biology; Receptor; Signal transduction; Cytokine receptor; Cytokine; Interleukin-7 receptor; Janus kinase 1; Janus kinase; Transcription factor; Immune system; Immunology; STAT3; Genetics; T cell; IL-2 receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00007314084,0.00007152095,0.0001438766,0.000041855,0.0001616381,0.000005223105,0.0001198503,0.00001796006,0.00906576],"category_scores_gemma":[0.00004665601,0.00005004407,0.0001162048,0.0001531003,0.00003146301,0.00002014513,0.0001064879,0.0002715457,0.000014602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000491996,"about_ca_system_score_gemma":0.00006806917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007394076,"about_ca_topic_score_gemma":0.000003415845,"domain_scores_codex":[0.999189,0.00005510237,0.000200071,0.0001175998,0.0003350749,0.0001032107],"domain_scores_gemma":[0.9995314,0.00003794692,0.0001024073,0.0002264099,0.00006185848,0.00003991243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000619202,0.00005090455,0.004820244,0.00001322029,0.00003567112,0.000002312553,0.0004280463,0.0004428343,0.9713889,0.0001038659,0.02236946,0.0002825707],"study_design_scores_gemma":[0.0005457869,0.0002506488,0.004625167,0.00004783522,0.00004719798,0.00007588149,0.0007085849,0.000826984,0.6649271,0.00004020498,0.3278164,0.0000881751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965113,0.00005944077,0.00003522952,0.001365652,0.0007930849,0.0001476022,0.0002582617,0.00001996517,0.0008094508],"genre_scores_gemma":[0.9975633,0.000002728741,0.0004218974,0.0009593272,0.000248826,0.000003567828,0.00004790192,0.00001400072,0.0007384269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3064618,"threshold_uncertainty_score":0.9918401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0325767027582285,"score_gpt":0.2794882980088088,"score_spread":0.2469115952505803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}