{"id":"W4280522196","doi":"10.1021/acs.analchem.1c05394","title":"Lipid A Structural Determination from a Single Colony","year":2022,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institute on Drug Abuse; National Institutes of Health; European Regional Development Fund; Genome British Columbia; Canada Foundation for Innovation; Genome Canada; Foundation for the National Institutes of Health","keywords":"Chemistry; Glycosidic bond; Lipid A; Tandem mass spectrometry; Tandem; Polymyxin; Chromatography; Mass spectrometry; Biochemistry; Combinatorial chemistry; Bacteria; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003047469,0.0008492072,0.0002346825,0.001124762,0.0003164767,0.0005027286,0.0004200061,0.0004789568,0.001678175],"category_scores_gemma":[0.0004679842,0.0002938832,0.0002801784,0.0004097938,0.0002010933,0.0004399763,0.0008102888,0.0005834514,0.001608945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001602412,"about_ca_system_score_gemma":0.0002310936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006731751,"about_ca_topic_score_gemma":0.001272689,"domain_scores_codex":[0.9995818,0.00004289579,0.00002938795,0.0001581035,0.0001521477,0.00003565396],"domain_scores_gemma":[0.9994544,0.00009522081,0.0001012214,0.00009670723,0.0001760321,0.00007639236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002193233,0.00001484784,0.000216422,0.00001228166,0.00000267274,0.00006138697,0.00001478282,0.00003429618,0.9956825,0.00003296838,0.00004246425,0.003863388],"study_design_scores_gemma":[0.000003873231,0.0001591575,0.00230408,0.000007723091,0.000009228594,0.0004162749,0.0000435781,0.002783899,0.9919196,0.0001190553,0.002219107,0.00001428632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7446697,0.00161065,0.2417681,0.0002761932,0.0001679476,0.0003728374,0.002194854,0.001600933,0.007338724],"genre_scores_gemma":[0.6623137,0.001822862,0.3206837,0.00024731,0.00004304975,0.0002368231,0.004569153,0.0003548348,0.009728543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001678175,"threshold_uncertainty_score":0.005614042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009687946040679343,"score_gpt":0.2484446119104617,"score_spread":0.2387566658697823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}