{"id":"W4280523270","doi":"10.1001/jamapsychiatry.2022.1017","title":"Copy Number Variant Risk Scores Associated With Cognition, Psychopathology, and Brain Structure in Youths in the Philadelphia Neurodevelopmental Cohort","year":2022,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Mental Health","keywords":"Neurocognitive; Psychopathology; Copy-number variation; Cohort; Psychology; Psychiatry; Cognition; Medicine; Clinical psychology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003967728,0.000150923,0.0001297581,0.00005149493,0.0002232007,0.00004263934,0.0001836874,0.00009907511,0.0001025153],"category_scores_gemma":[0.00004303895,0.0001211273,0.00002745611,0.0002101213,0.00007550536,0.000007825637,0.00009005448,0.0003449705,0.000001091019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002063006,"about_ca_system_score_gemma":0.0001217125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008482186,"about_ca_topic_score_gemma":0.0009036172,"domain_scores_codex":[0.9987168,0.0003526677,0.0002338182,0.000337089,0.0001460539,0.0002135519],"domain_scores_gemma":[0.9996085,0.00002531807,0.0001251293,0.0001880595,0.00002464321,0.00002838319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001684548,0.0001392475,0.9943998,0.000005661094,0.00004468913,0.00001471054,0.0008393619,0.0001235463,0.0005321203,0.000312707,0.003354073,0.00006559562],"study_design_scores_gemma":[0.002075368,0.000179312,0.9922647,0.0000117042,0.00002812186,0.0004354115,0.002463248,0.0000211727,0.00003632535,0.001434385,0.0008551754,0.0001950698],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951856,0.0001384956,0.00001732426,0.003127218,0.0002525405,0.0002869882,0.0005144601,0.000007477787,0.0004698875],"genre_scores_gemma":[0.9959597,0.00003841717,0.000395938,0.002734854,0.00009309313,0.00008185631,0.0006304786,0.00001758783,0.00004809287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002498897,"threshold_uncertainty_score":0.4939427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003857530791705837,"score_gpt":0.2065662507494881,"score_spread":0.2027087199577822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}