{"id":"W4280524043","doi":"10.1172/jci.insight.158144","title":"Age-dependent gray matter demyelination is associated with leptomeningeal neutrophil accumulation","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of British Columbia; University of Toronto","funders":"EMD Serono; Multiple Sclerosis Society of Canada","keywords":"Multiple sclerosis; Inflammation; Pathology; White matter; Experimental autoimmune encephalomyelitis; Medicine; Encephalomyelitis; Adoptive cell transfer; Grey matter; Leptomeninges; Immunology; Phenotype; Immune system; Microglia; Central nervous system; T cell; Biology; Magnetic resonance imaging; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002892443,0.0001664809,0.0002818608,0.0002403301,0.0004413842,0.00004129279,0.0001113036,0.00005275966,0.00187512],"category_scores_gemma":[0.0001138858,0.0001332502,0.00006903028,0.0004241661,0.00005984808,0.0001332777,0.0002031141,0.0004186201,0.00009885926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005500118,"about_ca_system_score_gemma":0.00006668072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000727548,"about_ca_topic_score_gemma":0.00004189098,"domain_scores_codex":[0.9978002,0.0001602912,0.0002525973,0.0003406601,0.001119594,0.0003266576],"domain_scores_gemma":[0.9992163,0.0001112886,0.0001283075,0.0002496269,0.0001919159,0.0001025388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001509562,0.001751951,0.8368398,0.0001435789,0.001297301,0.0006243692,0.01394824,0.001703281,0.05399276,0.0001152173,0.08129506,0.006778874],"study_design_scores_gemma":[0.003362967,0.0006111733,0.9756082,0.00004659482,0.00008334272,0.00001548862,0.0002381427,0.001480144,0.001899141,0.00003641553,0.01640921,0.0002091838],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868141,0.0001019454,0.00008834359,0.005206943,0.0001373266,0.0006802835,0.00003156406,0.000117694,0.006821844],"genre_scores_gemma":[0.9936491,0.00003000603,0.0001302871,0.00143312,0.0001353757,0.0002141672,0.0001871573,0.00003976786,0.004181007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1387684,"threshold_uncertainty_score":0.9990373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0697052899624053,"score_gpt":0.3309582736384974,"score_spread":0.2612529836760921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}