{"id":"W4280525750","doi":"10.1073/pnas.2200413119","title":"The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies","year":2022,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; BC Children's Hospital; University of British Columbia","funders":"National Center for Research Resources; National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Human Genome Research Institute; Institut de Cardiométabolisme et Nutrition; Agencia Estatal de Investigación; Instituto de Salud Carlos III; Biomedical Advanced Research and Development Authority; National Institutes of Health; Sorbonne Université; Instituto Colombiano de Crédito Educativo y Estudios Técnicos en el Exterior; Hellenic Foundation for Research and Innovation; Vlaamse regering; Université de Lyon; Regione Lombardia; Novo Nordisk Fonden; Agentura Pro Zdravotnický Výzkum České Republiky; George Mason University; Fondation Bettencourt Schueller; Hospital for Sick Children; European Regional Development Fund; Universitat de Barcelona; Centre National de la Recherche Scientifique; Vlaams Instituut voor Biotechnologie; Novo Nordisk; Hospices Civils de Lyon; Howard Hughes Medical Institute; Meath Foundation; NHLBI Division of Intramural Research; University of Hong Kong; Tokyo Medical and Dental University; University of New South Wales; KU Leuven; Fondation pour la Recherche Médicale; Eesti Teadusagentuur; Universiteit van Amsterdam; Medical Research Council; Tartu Ülikool; European Commission; Fundação de Amparo à Pesquisa do Estado de São Paulo; University of Sharjah; Jeffrey Modell Foundation; National Health and Medical Research Council; Fondation du Souffle; Fisher Center for Alzheimer's Research Foundation; Al Jalila Foundation; Assistance publique-Hôpitaux de Paris; Agence Nationale de la Recherche; Université de Bordeaux; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Institut National de la Santé et de la Recherche Médicale; Ministero della Salute; Croucher Foundation; Michael Smith Health Research BC; Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS); Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Fonds Wetenschappelijk Onderzoek; CSL Behring; Amsterdam University Medical Centers; Yale University; Institut des maladies génétiques Imagine; Aix-Marseille Université; National Center for Advancing Translational Sciences; Mercatus Center, George Mason University; JPB Foundation; Sanofi; Fondation de France; Université de Lille; Université Claude Bernard Lyon 1; St. Giles Foundation","keywords":"Coronavirus disease 2019 (COVID-19); Autoantibody; 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Medicine; Virology; Immunology; Internal medicine; Disease; Antibody; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009049282,0.0004483008,0.0003977637,0.0006141435,0.0002277552,0.0005297505,0.0002147444,0.0004456031,0.002699842],"category_scores_gemma":[0.002039296,0.0002667262,0.0010584,0.000423644,0.0002121101,0.0003868635,0.0004283373,0.0005535202,0.0006405739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002520413,"about_ca_system_score_gemma":0.0001747812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00394712,"about_ca_topic_score_gemma":0.003784109,"domain_scores_codex":[0.9993891,0.000174131,0.00004814448,0.0002106849,0.00007011792,0.0001078569],"domain_scores_gemma":[0.9987897,0.0002243786,0.0006010678,0.0001609205,0.0001087529,0.000115263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001694261,0.00001982374,0.9929981,0.00001358753,0.0001762759,0.0001096165,0.00003358943,0.0001956477,0.0006684253,0.00006087733,0.0002077761,0.005346788],"study_design_scores_gemma":[0.000004640567,0.0001032834,0.9977405,0.000009422854,0.00006411954,0.000572123,0.00003706749,0.0003882056,0.0002191512,0.00007889058,0.0007775065,0.000005045153],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918404,0.002288935,0.002053286,0.0001243628,0.0000398901,0.00001604276,0.001402233,0.00003932976,0.002195621],"genre_scores_gemma":[0.9969379,0.0007059534,0.0003480907,0.00006599877,0.00004356262,0.00001046949,0.0008250591,0.000006744147,0.001056231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00394712,"threshold_uncertainty_score":0.009031892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1071421719683968,"score_gpt":0.4293338009736836,"score_spread":0.3221916290052869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}