{"id":"W4280525977","doi":"10.1039/d2cc01783k","title":"Phosphinic acid-based inhibitors of tubulin polyglycylation","year":2022,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Tubulin; Flagellum; Chemistry; Microtubule; Cilium; Cell biology; Motility; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001456747,0.0005554585,0.0002900662,0.000297735,0.0002265648,0.0003097656,0.0003990208,0.0003630721,0.002981115],"category_scores_gemma":[0.0001453049,0.0001707715,0.000256658,0.0003042006,0.0001465732,0.0001612968,0.0002251723,0.000851353,0.0006652758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003864182,"about_ca_system_score_gemma":0.0003776993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001326768,"about_ca_topic_score_gemma":0.003251782,"domain_scores_codex":[0.9998584,0.00001961801,0.00001424199,0.0000215131,0.00003830011,0.00004799312],"domain_scores_gemma":[0.9999379,0.00001254954,0.00001237385,0.000006219733,0.00001054046,0.00002039129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008718952,0.0003923158,0.0001481384,0.0002434359,0.00004820843,0.0001834838,0.00002769933,0.0008030333,0.9801198,0.00112448,0.001351381,0.01468613],"study_design_scores_gemma":[0.0002858687,0.001558112,0.001564396,0.00001655323,0.00004120305,0.0002709861,0.00001461856,0.001546581,0.9754935,0.0001291502,0.01906446,0.00001474569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9226061,0.02576517,0.009940525,0.0006674039,0.0004592488,0.0004423608,0.002994367,0.001064196,0.03606059],"genre_scores_gemma":[0.9695277,0.01234375,0.003183797,0.0001917401,0.00005455876,0.0002204019,0.002055755,0.0000459863,0.01237628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002981115,"threshold_uncertainty_score":0.00997287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01384235733268775,"score_gpt":0.2575131466295607,"score_spread":0.243670789296873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}