{"id":"W4280526223","doi":"10.1016/j.bbrc.2022.05.031","title":"A novel C-domain-dependent inhibition of the rainbow trout CMP-sialic acid synthetase activity by CMP-deaminoneuraminic acid","year":2022,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Japan Society for the Promotion of Science; Kobayashi International Scholarship Foundation","keywords":"Sialic acid; Rainbow trout; Glycoconjugate; Chemistry; Enzyme; Substrate (aquarium); Biochemistry; Catalysis; Trout; Stereochemistry; N-Acetylneuraminic acid; Non-competitive inhibition; Biology; Fish <Actinopterygii>","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001337007,0.0003081694,0.0002584533,0.00009921118,0.0001209765,0.0002622038,0.0002603405,0.0002320412,0.001306169],"category_scores_gemma":[0.0001302502,0.000157769,0.0003996249,0.00009366243,0.0002530705,0.0001324452,0.0001829248,0.0004765829,0.0003465437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000516524,"about_ca_system_score_gemma":0.0004194265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002712873,"about_ca_topic_score_gemma":0.003664058,"domain_scores_codex":[0.9999015,0.000008667791,0.000008536683,0.00002283389,0.00002508867,0.00003336371],"domain_scores_gemma":[0.9999115,0.0000163251,0.0000179968,0.00001772962,0.00001118114,0.00002523499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008571032,0.00000913533,0.00005824171,0.000008992679,0.000003113073,0.00002441361,0.000002132247,0.00002173544,0.9994633,0.00004749512,0.00001219345,0.0002636845],"study_design_scores_gemma":[0.00001461391,0.0001376049,0.003472048,0.000001323125,0.000006694464,0.0000971277,0.000005261054,0.0004911196,0.9951527,0.00001363006,0.000604403,0.000003442119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945008,0.0008000878,0.00234747,0.00006888428,0.00004229252,0.00003798862,0.0003633942,0.00006821875,0.001770893],"genre_scores_gemma":[0.9950609,0.0002447876,0.001397314,0.0000459131,0.000007516669,0.00002722829,0.0004635304,0.00001680078,0.002736101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002712873,"threshold_uncertainty_score":0.005394101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04676440279629403,"score_gpt":0.3353406326433307,"score_spread":0.2885762298470367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}