{"id":"W4280526636","doi":"10.1016/j.ygyno.2022.05.005","title":"Homologous recombination deficiency (HRD) signature-3 in ovarian and uterine carcinosarcomas correlates with preclinical sensitivity to Olaparib, a poly (adenosine diphosphate [ADP]- ribose) polymerase (PARP) inhibitor","year":2022,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Stand Up To Cancer Canada; Cure JM Foundation; Fondazione Guido Berlucchi; Honorable Tina Brozman Foundation; Deborah Bunn Alley Ovarian Cancer Research Foundation; Stand Up To Cancer; Gilead Sciences","keywords":"Olaparib; PARP inhibitor; Medicine; In vivo; Cancer research; Ovarian cancer; Apoptosis; Poly ADP ribose polymerase; Biology; Internal medicine; Cancer; Polymerase; Enzyme; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001563822,0.0003990824,0.0009993407,0.0004623064,0.0003610851,0.00002493584,0.0001673249,0.0003921657,0.0007393053],"category_scores_gemma":[0.000582144,0.0003610352,0.0000907062,0.0009464468,0.0003545214,0.0001285236,0.000374412,0.001308291,0.00002371436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001431675,"about_ca_system_score_gemma":0.0006503717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004244294,"about_ca_topic_score_gemma":0.0005787159,"domain_scores_codex":[0.9959637,0.001049843,0.0007812291,0.001030404,0.0003973733,0.0007774833],"domain_scores_gemma":[0.9971502,0.001568801,0.0003445372,0.0004516369,0.0001424303,0.0003424267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03072613,0.01770414,0.6390379,0.0003344042,0.000444929,0.02305823,0.006715301,0.001743774,0.1376949,0.00453953,0.01261596,0.1253848],"study_design_scores_gemma":[0.0381792,0.06013073,0.8338773,0.0001505022,0.0003545076,0.008341203,0.001315648,0.001494942,0.01749105,0.002342315,0.03474924,0.001573331],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736007,0.002201252,0.0003593636,0.01923858,0.001358609,0.001769667,0.0001010837,0.0001574272,0.001213267],"genre_scores_gemma":[0.9896101,0.00009924656,0.001844286,0.007022946,0.0001761863,0.0006360758,0.0001115161,0.00004510482,0.0004544983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1948394,"threshold_uncertainty_score":0.9998842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0207253710445922,"score_gpt":0.316739489115801,"score_spread":0.2960141180712088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}