{"id":"W4280528502","doi":"10.1016/j.jmb.2022.167636","title":"Proteomic Characterization of a Candidate Polygenic Driver of Metabolism in Non-small Cell Lung Cancer","year":2022,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Cancer Society","keywords":"Interactome; Biology; Proteome; Gene; Downregulation and upregulation; Transcriptome; Phenotype; Proteomics; Computational biology; Genetics; Cancer research; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001294467,0.0002164037,0.000215152,0.0005590634,0.0002422449,0.0003616539,0.0001443885,0.0002304727,0.00107252],"category_scores_gemma":[0.0002550118,0.0001099231,0.000216594,0.000433934,0.0001073152,0.0001033949,0.0001684739,0.0001961318,0.0002221908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000151561,"about_ca_system_score_gemma":0.000163499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001381325,"about_ca_topic_score_gemma":0.001914279,"domain_scores_codex":[0.9999303,0.000008504002,0.000006330628,0.00001950549,0.00002017574,0.00001525665],"domain_scores_gemma":[0.9998555,0.00003026397,0.00004318111,0.00001166275,0.00002509879,0.00003422098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000322456,0.00002768769,0.02841802,0.00003695642,0.00008871347,0.000588257,0.00003531192,0.000113627,0.9683014,0.0001253858,0.0001470438,0.001795061],"study_design_scores_gemma":[0.00002306598,0.0002612498,0.8336902,0.0000094335,0.0001923134,0.003351056,0.0001652091,0.003565993,0.1562703,0.0002503307,0.002208633,0.00001228982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978178,0.0003550813,0.0007964906,0.00005654329,0.000007495002,0.00000674128,0.0006423024,0.00001556739,0.000302009],"genre_scores_gemma":[0.9977048,0.0001444589,0.0005883396,0.00004214905,0.000005871328,0.000006924683,0.0009469718,0.00000834593,0.0005521819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001381325,"threshold_uncertainty_score":0.003587961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003963799920187629,"score_gpt":0.2368458049982391,"score_spread":0.2328820050780515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}