{"id":"W4280529326","doi":"10.1200/edbk_349799","title":"Checkpoint Immunotherapy in Pediatrics: Here, Gone, and Back Again","year":2022,"lang":"en","type":"article","venue":"American Society of Clinical Oncology Educational Book","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Immunogenicity; Cancer; Immunotherapy; Pediatric oncology; Clinical trial; Lymphoma; Pediatric cancer; Oncology; Immune system; Internal medicine; Immunology; Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001053261,0.0005536859,0.0007655662,0.0008184813,0.000701742,0.002434527,0.0004808258,0.002158213,0.007663032],"category_scores_gemma":[0.002074012,0.0002478094,0.0004678854,0.0006807817,0.0009733727,0.004020415,0.0009346513,0.006835596,0.002609359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001125533,"about_ca_system_score_gemma":0.001143482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00162786,"about_ca_topic_score_gemma":0.004972153,"domain_scores_codex":[0.9996091,0.0001234835,0.00002861661,0.00004412359,0.0001359957,0.00005875904],"domain_scores_gemma":[0.9989997,0.0003811019,0.00008006688,0.0000370528,0.0002273635,0.0002747931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001324438,0.00009158624,0.001266484,0.001063499,0.0000324726,0.0004410577,0.0001816125,0.0001552498,0.001230128,0.01213517,0.5662864,0.4169839],"study_design_scores_gemma":[0.00002894726,0.0001038894,0.001079446,0.001274505,0.00002978823,0.001824814,0.0002476984,0.00009538016,0.0002456098,0.0055535,0.9895003,0.00001603756],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00137457,0.7497058,0.001003675,0.1874132,0.04571536,0.00001320893,0.00008882181,0.0001458893,0.01453945],"genre_scores_gemma":[0.01341732,0.7912802,0.002815526,0.09542857,0.05582811,0.00003387574,0.0001548112,0.0001171161,0.04092448],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007663032,"threshold_uncertainty_score":0.02563542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04650399474772465,"score_gpt":0.416699584552308,"score_spread":0.3701955898045834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}