{"id":"W4280531482","doi":"10.1503/cmaj.220044","title":"Time for a regulatory framework for pediatric medications in Canada","year":2022,"lang":"en","type":"article","venue":"Canadian Medical Association Journal","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McMaster Children's Hospital; CARE Canada; University of Toronto; University of Calgary; University of British Columbia; Health Canada; Western University","funders":"","keywords":"Dosing; Flexibility (engineering); Key (lock); Drug approval; Medicine; Drug; Computer science; Drug labeling; Intensive care medicine; Risk analysis (engineering); Pharmacology; Computer security","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02385912,0.000877687,0.001179718,0.002185153,0.01155775,0.01740391,0.005984249,0.02397622,0.02294526],"category_scores_gemma":[0.04977834,0.0011636,0.002487107,0.002169495,0.006077606,0.005186418,0.004844141,0.02270424,0.003700072],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.09869717,"about_ca_system_score_gemma":0.5433846,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9474837,"about_ca_topic_score_gemma":0.9585834,"domain_scores_codex":[0.9550263,0.003132884,0.002035636,0.002499928,0.02760755,0.009697729],"domain_scores_gemma":[0.8895,0.01020571,0.003488262,0.00183043,0.06232672,0.03264878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004911666,0.0001364707,0.002006614,0.0002326642,0.00003731392,0.0007667101,0.0009337792,0.0007010116,0.0009358778,0.1232676,0.8400697,0.03086326],"study_design_scores_gemma":[0.00004263686,0.00005075112,0.003909461,0.0006112594,0.00002531488,0.0001312469,0.0008647612,0.0003344893,0.0002087856,0.004304535,0.9894395,0.00007716852],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003973264,0.009348424,0.003718007,0.840015,0.01243819,0.0006401826,0.001581054,0.0005097757,0.1277761],"genre_scores_gemma":[0.07057124,0.01100508,0.02687421,0.7335457,0.004227651,0.0006784637,0.001892167,0.0003518243,0.1508537],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.9013028,"threshold_uncertainty_score":0.7161014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01903996994711012,"score_gpt":0.3135762499336229,"score_spread":0.2945362799865128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}