{"id":"W4280534867","doi":"10.1021/acschembio.2c00257","title":"Inhibiting C-4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens","year":2022,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Fungal Plant Pathogen Control","field":"Agricultural and Biological Sciences","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Toronto","funders":"Canadian Institutes of Health Research; Mitacs","keywords":"Biology; Ergosterol; Sterol; Saccharomyces cerevisiae; Plant disease; Biochemistry; Yeast; Oomycete; Alternative oxidase; Genetics; Gene; Microbiology; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003058941,0.0002483916,0.0003489234,0.00002202031,0.0002501586,0.00002746511,0.0004305872,0.0001093154,0.0003128006],"category_scores_gemma":[0.0001465733,0.0001002357,0.00007695425,0.00038828,0.00006166993,0.00005064855,0.0004296665,0.0003348535,0.00002508788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000493186,"about_ca_system_score_gemma":0.00001481271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005515714,"about_ca_topic_score_gemma":0.00004810706,"domain_scores_codex":[0.9982193,0.0000880248,0.0002907939,0.0006057126,0.0002016914,0.0005945445],"domain_scores_gemma":[0.9989757,0.00055656,0.0001077003,0.00009027814,0.00005203993,0.0002177449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002808115,0.0001573342,0.005272425,0.000003041726,0.00002256272,0.00007412028,0.00003647614,0.00001028118,0.9906788,0.0002329744,0.0002443038,0.002986879],"study_design_scores_gemma":[0.0007999892,0.001638379,0.002588448,0.00001146966,0.00003172175,0.0005339349,0.0002761859,0.00007068803,0.9317687,0.0001132783,0.06152103,0.0006461601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925963,0.0001149253,0.00001644011,0.001752929,0.0001264472,0.0003306773,0.004749238,0.0001074148,0.0002056761],"genre_scores_gemma":[0.9953988,0.000001715887,0.0008851814,0.002084155,0.0003759452,0.0001877074,0.0009999938,0.000003089019,0.00006343814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06127673,"threshold_uncertainty_score":0.4087493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0139867340622774,"score_gpt":0.2007474510539718,"score_spread":0.1867607169916944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}