{"id":"W4280535092","doi":"10.1093/infdis/jiac199","title":"Older Adults Mount Less Durable Humoral Responses to Two Doses of COVID-19 mRNA Vaccine but Strong Initial Responses to a Third Dose","year":2022,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Centre for Disease Control; University of British Columbia; St. Paul's Hospital; AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Alliance for Accelerating Excellence in Science in Africa; Providence Health Care; African Academy of Sciences; New Partnership for Africa's Development; Public Health Agency; Michael Smith Health Research BC; Canada Foundation for Innovation; Public Health Agency of Canada; Simon Fraser University; Government of the United Kingdom; National Institutes of Health; Wellcome Trust","keywords":"Immunogenicity; Immune system; Medicine; Immunology; Humoral immunity; Antibody; Young adult; Immunity; Virology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003186068,0.0002257908,0.0002241683,0.00009855734,0.0001354213,0.0001956236,0.00005860205,0.000252486,0.002157732],"category_scores_gemma":[0.0005676172,0.00007056225,0.0001545436,0.00005933024,0.0001111363,0.0002083365,0.0001573468,0.000346972,0.0003391479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001388305,"about_ca_system_score_gemma":0.0001257119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007520241,"about_ca_topic_score_gemma":0.0009140549,"domain_scores_codex":[0.9999183,0.00000981004,0.000008661607,0.0000208322,0.00001896779,0.00002337764],"domain_scores_gemma":[0.9996543,0.00004305227,0.000150714,0.00003156549,0.00005327605,0.00006708045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001930221,0.0007189505,0.7889937,0.0001706724,0.00008762487,0.0003195406,0.0008849718,0.0001607102,0.1773707,0.0000656397,0.0006392771,0.02865796],"study_design_scores_gemma":[0.00002024145,0.00402705,0.9891853,0.0000137247,0.0000250109,0.0003939916,0.0001567533,0.00005447483,0.005332011,0.00001440362,0.0007738596,0.000003178275],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994393,0.0001068218,0.00004958517,0.00001525838,0.0000050568,0.000008271947,0.00006250067,0.000003480685,0.0003097324],"genre_scores_gemma":[0.9991783,0.00005688207,0.00007127116,0.00007659503,0.000008418077,0.00000947503,0.0001328262,9.763646e-7,0.0004651281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002157732,"threshold_uncertainty_score":0.007218301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03721992860350135,"score_gpt":0.3745196143375925,"score_spread":0.3372996857340911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}