{"id":"W4280535517","doi":"10.1186/s13148-022-01282-y","title":"Folic acid intervention during pregnancy alters DNA methylation, affecting neural target genes through two distinct mechanisms","year":2022,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Economic and Social Research Council; Public Health Agency; Joint Programming Initiative A healthy diet for a healthy life","keywords":"DNA methylation; Human genetics; Folic acid; Gene; Pregnancy; Genetics; Biology; DNA; Bioinformatics; Methylation; Medicine; Computational biology; Internal medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007948986,0.000308525,0.000359119,0.00006068912,0.0005546437,0.00005420598,0.0004071834,0.0001672954,0.0001296662],"category_scores_gemma":[0.000497898,0.0003379743,0.0004622022,0.000220743,0.0001059629,0.00001119355,0.0006701816,0.0003458688,0.000008740806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000460798,"about_ca_system_score_gemma":0.00005488901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002375156,"about_ca_topic_score_gemma":0.00003614572,"domain_scores_codex":[0.9964967,0.0008129085,0.001046124,0.0008166139,0.0003583988,0.000469259],"domain_scores_gemma":[0.9984689,0.0001084501,0.0005021101,0.0006412009,0.0001274248,0.0001519055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002495236,0.0006130616,0.04062523,0.0001106165,0.0002477841,0.00002517821,0.000228253,0.01447063,0.8872593,0.0003089149,0.00004659561,0.05581491],"study_design_scores_gemma":[0.002528986,0.001749983,0.0348881,0.00004522041,0.0001291331,0.00001131662,0.0002000881,0.003080432,0.9441411,0.008900707,0.003604313,0.0007206273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8869472,0.008489006,0.1023086,0.0001008298,0.001429385,0.0004447497,0.00004894596,0.00004569983,0.0001855685],"genre_scores_gemma":[0.9892662,0.0006928481,0.008661415,0.0000829813,0.0005205421,0.00009860232,0.0003487956,0.00007736765,0.0002512289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.102319,"threshold_uncertainty_score":0.9999073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03651373753359539,"score_gpt":0.3522652044171015,"score_spread":0.3157514668835061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}