{"id":"W4280536692","doi":"10.12688/wellcomeopenres.17749.1","title":"The safety and immunogenicity of a combined pertussis containing vaccine Tdap for HIV infected pregnant women and their newborns (WoMANPOWER) – A study protocol for a randomized clinical trial","year":2022,"lang":"en","type":"preprint","venue":"Wellcome Open Research","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"European and Developing Countries Clinical Trials Partnership; Seqirus; National Institute for Health and Care Research; Canadian Child Health Clinician Scientist Program; Moderna; Novavax; Wellcome Trust; GlaxoSmithKline; Children's Hospital Foundation; Medical Research Council; London School of Hygiene and Tropical Medicine; Sanofi; Canadian Institutes of Health Research; Wellcome; Michael Smith Health Research BC; BC Children's Hospital; Bill and Melinda Gates Foundation; Johns Hopkins University; Department for International Development; Pfizer","keywords":"Medicine; Tetanus; Reactogenicity; Diphtheria; Pregnancy; Pediatrics; Randomized controlled trial; Obstetrics; Vaccination; Immunization; Immunology; Internal medicine; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03234387,0.00524676,0.006776128,0.001734489,0.002515089,0.003312094,0.003062957,0.006921052,0.0456271],"category_scores_gemma":[0.02579655,0.002852342,0.003754796,0.00180497,0.003040039,0.002836059,0.001445889,0.005669094,0.008685353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002948252,"about_ca_system_score_gemma":0.01342445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001100554,"about_ca_topic_score_gemma":0.002246256,"domain_scores_codex":[0.9831154,0.01102748,0.001658147,0.001270395,0.001387699,0.001540959],"domain_scores_gemma":[0.9889921,0.003138304,0.002315172,0.00156647,0.002168035,0.00182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9497991,0.01366544,0.0005218606,0.006451959,0.0007662669,0.0001809263,0.0002291266,0.0009948867,0.002129832,0.002043537,0.006281395,0.0169356],"study_design_scores_gemma":[0.9239902,0.05276073,0.001251351,0.001399661,0.0004524642,0.00005472706,0.00007085897,0.001008211,0.0006334272,0.001149231,0.01716921,0.00005976855],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.00497367,0.000320698,0.001219769,0.0001981118,0.0003804496,0.9911579,0.0007210767,0.00006912378,0.0009591087],"genre_scores_gemma":[0.004971313,0.0002246755,0.002089588,0.0002546601,0.000100606,0.9915678,0.0001754677,0.000006882521,0.0006089034],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.0456271,"threshold_uncertainty_score":0.1710528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1325478926913088,"score_gpt":0.4479563780827708,"score_spread":0.3154084853914619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}