{"id":"W4280536692","doi":"10.12688/wellcomeopenres.17749.1","title":"The safety and immunogenicity of a combined pertussis containing vaccine Tdap for HIV infected pregnant women and their newborns (WoMANPOWER) – A study protocol for a randomized clinical trial","year":2022,"lang":"en","type":"preprint","venue":"Wellcome Open Research","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"European and Developing Countries Clinical Trials Partnership; Seqirus; National Institute for Health and Care Research; Canadian Child Health Clinician Scientist Program; Moderna; Novavax; Wellcome Trust; GlaxoSmithKline; Children's Hospital Foundation; Medical Research Council; London School of Hygiene and Tropical Medicine; Sanofi; Canadian Institutes of Health Research; Wellcome; Michael Smith Health Research BC; BC Children's Hospital; Bill and Melinda Gates Foundation; Johns Hopkins University; Department for International Development; Pfizer","keywords":"Medicine; Tetanus; Reactogenicity; Diphtheria; Pregnancy; Pediatrics; Randomized controlled trial; Obstetrics; Vaccination; Immunization; Immunology; Internal medicine; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.03010725,0.0004416593,0.00249285,0.0002481382,0.001862935,0.0003824503,0.00122831,0.0004630158,0.00046351],"category_scores_gemma":[0.004043903,0.0002565708,0.0004118471,0.0002368624,0.0004680956,0.00008950373,0.00608381,0.001464984,0.000001744474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001275302,"about_ca_system_score_gemma":0.0006663705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001043253,"about_ca_topic_score_gemma":0.0002460981,"domain_scores_codex":[0.9880621,0.008110477,0.001986469,0.0009781189,0.00007614591,0.0007867285],"domain_scores_gemma":[0.9812633,0.0162445,0.0007810616,0.0009920589,0.000641357,0.00007767284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9826402,0.002112815,0.00138717,0.0002255619,0.002870234,4.75646e-7,0.00235383,0.000001131035,0.001500724,0.000532144,0.0006572859,0.005718424],"study_design_scores_gemma":[0.8691293,0.01545104,0.00235273,0.0001910258,0.0001222537,0.000006303659,0.003349465,0.0001502805,0.0001720615,0.001552564,0.1071798,0.000343196],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.45563,0.0003015168,0.00009596667,0.0006944258,0.0005790562,0.5421147,0.0003572931,0.00003313822,0.000193845],"genre_scores_gemma":[0.2226837,0.0002526791,0.00004988109,0.00001261232,0.00009578878,0.77416,0.0001712655,0.00005742518,0.002516662],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.2329464,"threshold_uncertainty_score":0.9999887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1325478926913088,"score_gpt":0.4479563780827708,"score_spread":0.3154084853914619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}