{"id":"W4280537252","doi":"10.1016/j.tibs.2022.04.005","title":"SRC homology 3 domains: multifaceted binding modules","year":2022,"lang":"en","type":"review","venue":"Trends in Biochemical Sciences","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; PROTEO","funders":"Canadian Institutes of Health Research","keywords":"SH3 domain; Proto-oncogene tyrosine-protein kinase Src; Computational biology; Homology (biology); Allosteric regulation; SH2 domain; Context (archaeology); Biology; Plasma protein binding; Modular design; Cell biology; Phosphorylation; Amino acid; Genetics; Computer science; Receptor; Programming language","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007206667,0.001408176,0.001972644,0.001309363,0.0002123688,0.001549164,0.001406718,0.001344708,0.002045415],"category_scores_gemma":[0.0004044854,0.000466771,0.0004134132,0.001992873,0.0007319677,0.001767118,0.0009890938,0.001815304,0.00253756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008307093,"about_ca_system_score_gemma":0.0009101892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005427949,"about_ca_topic_score_gemma":0.001081985,"domain_scores_codex":[0.9997831,0.00002510262,0.00002393879,0.0000541818,0.000074323,0.00003924963],"domain_scores_gemma":[0.9998661,0.00005135229,0.0000289447,0.000006202813,0.00002811433,0.0000192382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002360562,0.00005212573,0.0002365529,0.00601399,0.0001086881,0.0002158739,0.00004844522,0.0006384641,0.011839,0.007780008,0.01808082,0.95475],"study_design_scores_gemma":[0.00005986074,0.0001195404,0.0012875,0.0009799973,0.0002267126,0.001322933,0.00005269671,0.000313896,0.003992592,0.004165845,0.9874361,0.00004232119],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000514763,0.9969817,0.0007514849,0.0003584594,0.0002119305,0.000006191363,0.00005323018,0.00002501421,0.001097153],"genre_scores_gemma":[0.002375962,0.9946964,0.000646315,0.0003779312,0.0002297955,0.00001238677,0.0001578647,0.000003001488,0.00150038],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002045415,"threshold_uncertainty_score":0.006842613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08494500193053893,"score_gpt":0.3984228134567671,"score_spread":0.3134778115262281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}