{"id":"W4280537263","doi":"10.1002/wrna.1738","title":"Targeting <scp>DEAD</scp>‐box <scp>RNA</scp> helicases: The emergence of molecular staples","year":2022,"lang":"en","type":"review","venue":"Wiley Interdisciplinary Reviews - RNA","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"RNA; Helicase; eIF4A; Biology; Non-coding RNA; Computational biology; RNA-binding protein; RNA Helicase A; Function (biology); Transcription (linguistics); Cell biology; Riboswitch; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002708719,0.001193813,0.002828512,0.0002629276,0.0006803094,0.0001099694,0.003023833,0.0004716652,0.0002554462],"category_scores_gemma":[0.002614291,0.0008243217,0.002540139,0.0009096562,0.0003970304,0.00002517915,0.005654371,0.001376203,0.0001528334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001004815,"about_ca_system_score_gemma":0.0004846475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002390703,"about_ca_topic_score_gemma":0.00001275619,"domain_scores_codex":[0.991982,0.001878704,0.002493573,0.001535286,0.0008412186,0.001269238],"domain_scores_gemma":[0.9947845,0.0005708908,0.001772623,0.002295953,0.0001787313,0.0003973393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001238177,0.0003792573,0.00001382808,0.02590147,0.001133341,0.0002313504,0.0005703426,0.00005047165,0.04244706,0.00009735169,0.2927754,0.6363878],"study_design_scores_gemma":[0.0001589325,0.0007012152,8.391643e-7,0.007806219,0.0004927185,0.0001315861,0.0009656616,0.00002930084,0.00149696,0.00005085193,0.9879425,0.0002232436],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001847561,0.9900141,0.0005767528,0.00004961529,0.0005658228,0.002737156,0.0003615621,0.00003509806,0.003812373],"genre_scores_gemma":[0.0001627183,0.9915594,0.0003919735,0.0001330233,0.0006418924,0.001236627,0.001403322,0.0002106159,0.004260419],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6951671,"threshold_uncertainty_score":0.9994208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04625023842645476,"score_gpt":0.3573657156221346,"score_spread":0.3111154771956798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}