{"id":"W4280539175","doi":"10.1016/j.isci.2022.104432","title":"Functional analysis of the Candida albicans kinome reveals Hrr25 as a regulator of antifungal susceptibility","year":2022,"lang":"en","type":"article","venue":"iScience","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Research Council Canada; National Institutes of Health; Canadian Institutes of Health Research; Genome Canada; Canada Research Chairs; Canadian Institute for Advanced Research; Merck","keywords":"Kinome; Candida albicans; Echinocandins; Echinocandin; Caspofungin; Anidulafungin; Biology; Drug resistance; Antifungal drug; Kinase; Mediator; Casein kinase 1; Drug; Micafungin; Computational biology; Microbiology; Antifungal; Pharmacology; Protein kinase A; Amphotericin B; Genetics; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007397974,0.0002359254,0.0001319675,0.0002727599,0.0001592798,0.0002227198,0.0002034957,0.0001750457,0.001513232],"category_scores_gemma":[0.00009004567,0.00006454319,0.0002013738,0.0001275872,0.0001444427,0.0001144584,0.0001415761,0.0002729271,0.0005009782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002969996,"about_ca_system_score_gemma":0.0001399477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007988376,"about_ca_topic_score_gemma":0.001040062,"domain_scores_codex":[0.999931,0.000008305808,0.000004943287,0.0000185801,0.00002065923,0.00001665048],"domain_scores_gemma":[0.9999462,0.000008219211,0.00001315046,0.000007779544,0.000006107568,0.00001862594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000598943,0.000006840342,0.0002784715,0.00001054887,0.000002651377,0.00007710091,0.000005297034,0.00006592244,0.9987417,0.0000822982,0.00002307532,0.0006463056],"study_design_scores_gemma":[0.00001018037,0.0001010416,0.03917324,0.000008023686,0.00002084244,0.000670996,0.00005124398,0.003311237,0.9541336,0.0001484088,0.0023616,0.000009524419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995266,0.0008133284,0.0019926,0.00008393431,0.00001273115,0.000009267846,0.0005460411,0.00005290814,0.001223247],"genre_scores_gemma":[0.9972926,0.00014444,0.0008915993,0.00003603473,0.00000264435,0.000005754514,0.0005374997,0.000007543492,0.001081813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001513232,"threshold_uncertainty_score":0.005062282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02070804562941643,"score_gpt":0.2788061756581567,"score_spread":0.2580981300287403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}