{"id":"W4280542156","doi":"10.1021/acsomega.1c07226","title":"Functional Characterization of Sodium Channel Inhibitors at the Delta-Opioid Receptor","year":2022,"lang":"en","type":"article","venue":"ACS Omega","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Institute of Neurosciences, Mental Health and Addiction; Natural Sciences and Engineering Research Council of Canada","keywords":"Allosteric regulation; G protein-coupled receptor; Opioid; Receptor; δ-opioid receptor; Opioid receptor; Chemistry; Functional selectivity; Sodium channel; Pharmacology; Allosteric modulator; Medicine; Sodium; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002159974,0.0000912834,0.00008534778,0.00002908746,0.0002783136,0.000009371813,0.0001341335,0.0000530947,0.0003865992],"category_scores_gemma":[0.00001838341,0.00007485648,0.00007285139,0.0001024611,0.00003325303,0.000003651394,0.00025157,0.00007856733,0.00001103498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002503771,"about_ca_system_score_gemma":0.00004203788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009115094,"about_ca_topic_score_gemma":0.000002889503,"domain_scores_codex":[0.9992335,0.00005907029,0.0001719163,0.0001980849,0.0001980579,0.0001394077],"domain_scores_gemma":[0.9995953,0.000008183502,0.000118849,0.0001904908,0.00005693007,0.00003018021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008163791,0.00002953636,0.0001249788,0.000005272239,0.00002353218,1.912298e-7,0.00008473056,0.00005651348,0.9926789,0.00008576935,0.006357003,0.0004719676],"study_design_scores_gemma":[0.0001986976,0.0001516459,0.0002912892,0.000002105682,0.00000734516,0.00000476701,0.0001064096,0.00002479374,0.8732527,0.00004417242,0.1258296,0.00008644012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978133,0.0001892078,0.0006531338,0.0002878408,0.0007053688,0.000134951,0.0001001826,0.000008713243,0.000107232],"genre_scores_gemma":[0.9936627,0.00006155279,0.00002813026,0.0003426131,0.0003887522,0.00006961749,0.001350131,0.00001777055,0.004078696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1194726,"threshold_uncertainty_score":0.4232991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011743820991685,"score_gpt":0.2024205970973685,"score_spread":0.1923031588874516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}