{"id":"W4280542156","doi":"10.1021/acsomega.1c07226","title":"Functional Characterization of Sodium Channel Inhibitors at the Delta-Opioid Receptor","year":2022,"lang":"en","type":"article","venue":"ACS Omega","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Institute of Neurosciences, Mental Health and Addiction; Natural Sciences and Engineering Research Council of Canada","keywords":"Allosteric regulation; G protein-coupled receptor; Opioid; Receptor; δ-opioid receptor; Opioid receptor; Chemistry; Functional selectivity; Sodium channel; Pharmacology; Allosteric modulator; Medicine; Sodium; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002286712,0.000239005,0.0002655205,0.0002490719,0.0001491848,0.0002277688,0.0003918139,0.0002070394,0.003460592],"category_scores_gemma":[0.0001866419,0.0001082323,0.0002152546,0.0002100829,0.000104321,0.0002359103,0.00008145755,0.0003037612,0.000928104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002440266,"about_ca_system_score_gemma":0.0001742764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001167903,"about_ca_topic_score_gemma":0.001066924,"domain_scores_codex":[0.9998871,0.00001291363,0.000009810406,0.00001591269,0.00005092381,0.0000233297],"domain_scores_gemma":[0.9999031,0.00002028352,0.00001371105,0.000006091216,0.0000377595,0.00001905838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001069478,0.00002920175,0.00007715371,0.0000384962,0.000006430883,0.00002526529,0.00001105103,0.00008359547,0.9974546,0.000059117,0.00008412828,0.002024126],"study_design_scores_gemma":[0.0000214368,0.0003965413,0.003482687,0.000006384133,0.00002058572,0.0002007511,0.00002886786,0.002680406,0.9893059,0.00003399396,0.00381479,0.000007576193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674603,0.005593556,0.01245098,0.0003543185,0.00004339361,0.0001715164,0.002429919,0.0002656371,0.01123042],"genre_scores_gemma":[0.959065,0.004598814,0.01623672,0.0002860351,0.00001552134,0.0001315859,0.005611943,0.0001333105,0.013921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003460592,"threshold_uncertainty_score":0.01157683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011743820991685,"score_gpt":0.2024205970973685,"score_spread":0.1923031588874516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}