{"id":"W4280542175","doi":"10.1093/genetics/iyac074","title":"Reconstruction of full-length LINE-1 progenitors from ancestral genomes","year":2022,"lang":"en","type":"article","venue":"Genetics","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of British Columbia; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Retrotransposon; Subfamily; ORFS; Genome; Genetics; Human genome; Zinc finger; Evolutionary biology; Gene; Transposable element; Computational biology; Peptide sequence; Open reading frame; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000229059,0.0004274558,0.0003245698,0.0009097527,0.000357754,0.0008171336,0.00064674,0.0004444511,0.001474729],"category_scores_gemma":[0.0008403083,0.0004065681,0.0004301231,0.0008397563,0.0002346539,0.0003783442,0.000452068,0.0006947393,0.000868933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004063739,"about_ca_system_score_gemma":0.0003825859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001090275,"about_ca_topic_score_gemma":0.00164303,"domain_scores_codex":[0.9998952,0.00002429967,0.000005464869,0.00003903312,0.00002180636,0.00001411845],"domain_scores_gemma":[0.999725,0.00009272487,0.00005870615,0.00004991633,0.00004031941,0.00003321044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001131954,0.0001135725,0.03378218,0.0004830966,0.0001363899,0.0006008812,0.0008434744,0.03692843,0.8668239,0.006169064,0.0005878385,0.0523993],"study_design_scores_gemma":[0.000195112,0.0008764861,0.1325842,0.0002198829,0.0003782782,0.002752355,0.00122155,0.3546781,0.4352576,0.009954615,0.06171266,0.0001691402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9342302,0.0004676485,0.05933035,0.0000616227,0.00001289676,0.00003563457,0.003531975,0.000532073,0.001797587],"genre_scores_gemma":[0.8412005,0.001029033,0.131127,0.0000443114,0.00001140214,0.00006268415,0.02443269,0.0003922325,0.0017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001474729,"threshold_uncertainty_score":0.004933476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02342164936196258,"score_gpt":0.2123254933578992,"score_spread":0.1889038439959366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}