{"id":"W4280542423","doi":"10.1101/2022.04.21.488729","title":"SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Novo Nordisk Fonden; Novo Nordisk; Alzheimer Forschung Initiative","keywords":"Islet; Endocytic cycle; Amyloid (mycology); Genetically modified mouse; Endocrinology; Internal medicine; Cell biology; Receptor; Amylin; Biology; Transgene; Chemistry; Endocytosis; Biochemistry; Insulin; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000267763,0.0004933513,0.0005501977,0.000197079,0.0001471666,0.0006353387,0.0003867311,0.0004313973,0.003208535],"category_scores_gemma":[0.0001633158,0.0001721482,0.0006132103,0.00008860125,0.0003692892,0.0004142972,0.0002964222,0.001017177,0.001378027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002320007,"about_ca_system_score_gemma":0.0002333402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000142781,"about_ca_topic_score_gemma":0.0001278038,"domain_scores_codex":[0.9997913,0.00002946349,0.00002179183,0.00004697076,0.00004018756,0.00007026397],"domain_scores_gemma":[0.9996856,0.0000240234,0.00009594564,0.00003222643,0.00004482756,0.0001174035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005336016,0.00006123893,0.0003415021,0.00009679898,0.00001110122,0.00008676615,0.000009587038,0.00004389185,0.9976901,0.00009249422,0.00007234464,0.0009605928],"study_design_scores_gemma":[0.0001044973,0.0010342,0.008661387,0.00001975367,0.00006110225,0.0008232485,0.0001227073,0.001320988,0.9844393,0.0001285901,0.003271549,0.0000126845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898884,0.002922512,0.004568797,0.0002161125,0.00008652768,0.00003452367,0.0005422547,0.0002057455,0.001535077],"genre_scores_gemma":[0.9909254,0.001603523,0.002112983,0.0001829822,0.0000526973,0.00005468449,0.0009405071,0.00004693624,0.004080237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003208535,"threshold_uncertainty_score":0.01073366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01773740226818533,"score_gpt":0.2536259797115534,"score_spread":0.2358885774433681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}