{"id":"W4280542612","doi":"10.3390/biomedicines10051110","title":"Inhaled Corticosteroids Selectively Alter the Microbiome and Host Transcriptome in the Small Airways of Patients with Chronic Obstructive Pulmonary Disease","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Simon Fraser University; St. Paul's Hospital; University of British Columbia","funders":"British Columbia Lung Association","keywords":"Formoterol; COPD; Salmeterol; Fluticasone; Microbiome; Medicine; Budesonide; Internal medicine; Immunology; Biology; Asthma; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002412997,0.0001574918,0.0004812628,0.0002704144,0.0003195285,0.0004720062,0.00008431133,0.0003110713,0.001167997],"category_scores_gemma":[0.0009020156,0.00009508439,0.0002531392,0.000336039,0.0002231417,0.0001912819,0.0002619522,0.0003477391,0.000154774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002635708,"about_ca_system_score_gemma":0.0003505209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001399336,"about_ca_topic_score_gemma":0.002809185,"domain_scores_codex":[0.9997126,0.00007858935,0.00002064033,0.0000632585,0.00006061423,0.00006416038],"domain_scores_gemma":[0.9996483,0.00008468948,0.0001256484,0.00001710431,0.00004952989,0.00007474819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004052848,0.000293765,0.8846795,0.000246974,0.0002532388,0.0003633962,0.0004311466,0.0001683434,0.08744574,0.0000517495,0.0005427001,0.02147062],"study_design_scores_gemma":[0.00002101696,0.0004660145,0.9974113,0.00002087155,0.00006995499,0.0001584761,0.0002854955,0.0001290388,0.001033857,0.00004344565,0.0003563565,0.000004209405],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981843,0.001122235,0.00006092927,0.0001047356,0.000009157078,0.00001228239,0.0002190154,0.000002911766,0.0002843456],"genre_scores_gemma":[0.9989126,0.0003888066,0.0001378517,0.0001351326,0.00001278915,0.00001701408,0.0002599954,0.000001726079,0.0001341667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001399336,"threshold_uncertainty_score":0.003907263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006360191434862074,"score_gpt":0.2096290151339112,"score_spread":0.2032688236990492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}