{"id":"W4280542612","doi":"10.3390/biomedicines10051110","title":"Inhaled Corticosteroids Selectively Alter the Microbiome and Host Transcriptome in the Small Airways of Patients with Chronic Obstructive Pulmonary Disease","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Simon Fraser University; St. Paul's Hospital; University of British Columbia","funders":"British Columbia Lung Association","keywords":"Formoterol; COPD; Salmeterol; Fluticasone; Microbiome; Medicine; Budesonide; Internal medicine; Immunology; Biology; Asthma; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001463003,0.0001357483,0.0001383586,0.00007521096,0.0001491329,0.000006878128,0.0002102831,0.00003198398,0.00001238874],"category_scores_gemma":[0.000008607059,0.00007502778,0.00003206314,0.0002647358,0.0002940083,0.00000339105,0.00007394925,0.0001171101,3.125432e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003296991,"about_ca_system_score_gemma":0.0001232748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006605248,"about_ca_topic_score_gemma":0.00007094342,"domain_scores_codex":[0.9990987,0.0001305013,0.0001899367,0.0002533582,0.0001160036,0.0002114612],"domain_scores_gemma":[0.9995691,0.00001883834,0.00008982598,0.0002184806,0.00005444176,0.00004931844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006895933,0.0002609045,0.1319954,0.0001123843,0.00003864485,0.00001328692,0.0009766315,0.000001870584,0.8646213,0.00001367128,0.0002380933,0.001038145],"study_design_scores_gemma":[0.001170952,0.0008957925,0.9882717,0.00001824664,0.00004112509,0.0000339343,0.0004584661,0.000005939113,0.002568476,0.00000961318,0.00641396,0.0001117697],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956226,0.002675233,0.00001905854,0.0008076194,0.00009091046,0.0005614356,0.0001954913,0.000003476373,0.00002416611],"genre_scores_gemma":[0.9989756,0.0000744604,0.00001619979,0.0005377888,0.00006894849,0.00006686665,0.0001962203,0.00001380156,0.00005007235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8620529,"threshold_uncertainty_score":0.3059544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006360191434862074,"score_gpt":0.2096290151339112,"score_spread":0.2032688236990492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}