{"id":"W4280545103","doi":"10.1021/acs.jafc.1c07161","title":"Chicken Muscle-Derived ACE2 Upregulating Peptide VVHPKESF Inhibits Angiotensin II-Stimulated Inflammation in Vascular Smooth Muscle Cells <i>via</i> the ACE2/Ang (1–7)/MasR Axis","year":2022,"lang":"en","type":"article","venue":"Journal of Agricultural and Food Chemistry","topic":"Protein Hydrolysis and Bioactive Peptides","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Killam Trusts; Alberta Innovates - Technology Futures; Egg Farmers of Canada","keywords":"Inflammation; Downregulation and upregulation; Angiotensin II; Vascular smooth muscle; Receptor; Internal medicine; Endocrinology; Chemistry; Peptide; Renin–angiotensin system; Angiotensin-converting enzyme 2; Medicine; Smooth muscle; Biochemistry; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000407774,0.0002596733,0.0002984894,0.00003123366,0.0003993317,0.0000552312,0.0002536369,0.0001507041,0.00002502881],"category_scores_gemma":[0.00005271259,0.0001611394,0.0002749242,0.0002410028,0.00008430594,0.0000308587,0.0003866659,0.0004405458,3.998566e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000597293,"about_ca_system_score_gemma":0.00003943469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002627344,"about_ca_topic_score_gemma":0.00002061519,"domain_scores_codex":[0.9984214,0.0001069892,0.0005321077,0.0002987204,0.0003534775,0.000287265],"domain_scores_gemma":[0.998981,0.0000232165,0.0005206386,0.000192233,0.0001798429,0.0001030717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004509876,0.00006740874,0.0001432767,0.00002460861,0.0001198927,0.000003572965,0.0003135153,0.003916311,0.9927065,5.821741e-7,0.0002225479,0.00243662],"study_design_scores_gemma":[0.001024429,0.0003894727,0.05245627,0.00005805858,0.00006958991,0.00006154318,0.0009833971,0.0001664971,0.9414237,0.00003524459,0.003037016,0.0002947555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968244,0.001858422,0.00001560912,0.0009248402,0.00005718066,0.0001895427,0.00001776166,0.0000089481,0.0001032493],"genre_scores_gemma":[0.9989321,0.0001558845,0.0002091511,0.0000769152,0.0004394533,0.00001313087,0.00006541023,0.00001542164,0.00009254496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.052313,"threshold_uncertainty_score":0.6571074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005794124763332507,"score_gpt":0.1835890066359906,"score_spread":0.1777948818726581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}