{"id":"W4280545103","doi":"10.1021/acs.jafc.1c07161","title":"Chicken Muscle-Derived ACE2 Upregulating Peptide VVHPKESF Inhibits Angiotensin II-Stimulated Inflammation in Vascular Smooth Muscle Cells <i>via</i> the ACE2/Ang (1–7)/MasR Axis","year":2022,"lang":"en","type":"article","venue":"Journal of Agricultural and Food Chemistry","topic":"Protein Hydrolysis and Bioactive Peptides","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Killam Trusts; Alberta Innovates - Technology Futures; Egg Farmers of Canada","keywords":"Inflammation; Downregulation and upregulation; Angiotensin II; Vascular smooth muscle; Receptor; Internal medicine; Endocrinology; Chemistry; Peptide; Renin–angiotensin system; Angiotensin-converting enzyme 2; Medicine; Smooth muscle; Biochemistry; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008398051,0.0002566308,0.0001974213,0.00009321044,0.00007062789,0.0001431603,0.00007476169,0.0001623921,0.0006332823],"category_scores_gemma":[0.00005741431,0.00005820628,0.0002142889,0.00003879561,0.0001386718,0.0001425843,0.00007393051,0.0003194934,0.0001063225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009009978,"about_ca_system_score_gemma":0.0001064438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002775114,"about_ca_topic_score_gemma":0.0004858058,"domain_scores_codex":[0.999957,0.000009013508,0.00000434327,0.000009359364,0.000007668583,0.00001271501],"domain_scores_gemma":[0.9999647,0.000006461255,0.00001046879,0.000002435439,0.000005186711,0.00001065649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002584481,0.00003503828,0.0001077726,0.00003690977,0.000004576515,0.00002653992,0.000005907795,0.00002590526,0.9983478,0.00001480704,0.00001097156,0.001125367],"study_design_scores_gemma":[0.00004956436,0.002466241,0.007025456,0.000007497465,0.00003144202,0.0001863485,0.00003830044,0.0004851746,0.9884144,0.00002280177,0.001267578,0.000005194679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981986,0.0006805217,0.0006458752,0.00002959701,0.00001539322,0.00001324204,0.00006130608,0.00000928285,0.0003463287],"genre_scores_gemma":[0.9966086,0.0006207153,0.001717282,0.00004289475,0.00001445644,0.00001812354,0.0001715631,0.000005714639,0.0008006813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006332823,"threshold_uncertainty_score":0.002118468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005794124763332507,"score_gpt":0.1835890066359906,"score_spread":0.1777948818726581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}