{"id":"W4280546035","doi":"10.1016/j.jaip.2022.04.037","title":"Mepolizumab Reduces Hypereosinophilic Syndrome Flares Irrespective of Blood Eosinophil Count and Interleukin-5","year":2022,"lang":"en","type":"article","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Eosinophilic Disorders and Syndromes","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada)","funders":"Universitaire Ziekenhuizen Leuven, KU Leuven; University of California, San Diego; Centre hospitalier régional universitaire de Lille; Centre Hospitalier Universitaire de Nantes; Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze; Vifor Pharma; University of South Carolina; Genentech; Centre Hospitalier Universitaire de Toulouse; Yale University; Cincinnati Children's Hospital Medical Center; Mayo Foundation for Medical Education and Research; GlaxoSmithKline; AstraZeneca","keywords":"Mepolizumab; Medicine; Eosinophil; Hypereosinophilic syndrome; Interleukin 5; Eosinophilia; Immunology; Interleukin; Cytokine; Asthma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002415674,0.0001668944,0.0007331399,0.0002009573,0.0001794841,0.00001292273,0.00028149,0.0001352506,0.0001144583],"category_scores_gemma":[0.001565855,0.0001160035,0.0001221625,0.0002190403,0.0008431667,0.0002392719,0.0003013971,0.00149594,0.000001230812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000037832,"about_ca_system_score_gemma":0.0002287073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001616884,"about_ca_topic_score_gemma":0.00002393983,"domain_scores_codex":[0.9969465,0.001144502,0.001176069,0.0001942468,0.0003206694,0.0002180544],"domain_scores_gemma":[0.9957494,0.002698555,0.0009859236,0.0002708577,0.0002183395,0.00007694555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"observational","study_design_scores_codex":[0.2329428,0.07115879,0.1052273,0.0004368811,0.2368304,0.03314919,0.08383688,0.0003644819,0.06963317,0.04726513,0.005463593,0.1136914],"study_design_scores_gemma":[0.02012392,0.04632,0.63151,0.0005352655,0.00781159,0.2037933,0.06832723,0.00005456167,0.0006172152,0.00878929,0.01157556,0.0005420861],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9535679,0.03230574,0.000001285399,0.01249995,0.0004170334,0.0001514752,0.000004178227,0.000005684901,0.001046774],"genre_scores_gemma":[0.9651685,0.03378943,0.0001484379,0.000674555,0.00004979548,0.000003951549,0.000001246936,0.00001516701,0.0001488577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5262827,"threshold_uncertainty_score":0.6499197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946369654548441,"score_gpt":0.324274220626849,"score_spread":0.3048105240813646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}