{"id":"W4280546035","doi":"10.1016/j.jaip.2022.04.037","title":"Mepolizumab Reduces Hypereosinophilic Syndrome Flares Irrespective of Blood Eosinophil Count and Interleukin-5","year":2022,"lang":"en","type":"article","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Eosinophilic Disorders and Syndromes","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada)","funders":"Universitaire Ziekenhuizen Leuven, KU Leuven; University of California, San Diego; Centre hospitalier régional universitaire de Lille; Centre Hospitalier Universitaire de Nantes; Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze; Vifor Pharma; University of South Carolina; Genentech; Centre Hospitalier Universitaire de Toulouse; Yale University; Cincinnati Children's Hospital Medical Center; Mayo Foundation for Medical Education and Research; GlaxoSmithKline; AstraZeneca","keywords":"Mepolizumab; Medicine; Eosinophil; Hypereosinophilic syndrome; Interleukin 5; Eosinophilia; Immunology; Interleukin; Cytokine; Asthma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005501704,0.0002828675,0.0007858591,0.0001375267,0.0001054335,0.0001808763,0.0001807666,0.0002486219,0.002031468],"category_scores_gemma":[0.0006208698,0.0001253738,0.000396849,0.00009084796,0.0001473931,0.000190618,0.0001205613,0.0007306763,0.000232491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001701069,"about_ca_system_score_gemma":0.0002951186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003216076,"about_ca_topic_score_gemma":0.001091506,"domain_scores_codex":[0.9998112,0.00006931798,0.00001750938,0.00001982813,0.00003410059,0.00004801759],"domain_scores_gemma":[0.9996501,0.000105787,0.0001207254,0.00001782493,0.00002696023,0.00007856225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.3644595,0.019335,0.03300347,0.001828366,0.002866958,0.0002009062,0.0001527854,0.002571624,0.3022035,0.0001687028,0.002719126,0.2704901],"study_design_scores_gemma":[0.1150087,0.3905476,0.4403897,0.0002059664,0.002400193,0.0009764412,0.0001114757,0.003249035,0.04215075,0.0002418759,0.004682341,0.00003594465],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977958,0.001104841,0.0001244467,0.00009090197,0.00001282321,0.0001183103,0.0001540808,0.00002198773,0.0005768047],"genre_scores_gemma":[0.9986363,0.0003481483,0.0002248992,0.00008383599,0.00002243042,0.00009181372,0.0001740337,0.000003363419,0.0004152901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002031468,"threshold_uncertainty_score":0.006795943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946369654548441,"score_gpt":0.324274220626849,"score_spread":0.3048105240813646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}