{"id":"W4280552086","doi":"10.1038/s41588-022-01058-3","title":"Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation","year":2022,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":739,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Impact; Hamilton Health Sciences; University of Toronto; McMaster University; Population Health Research Institute","funders":"National Heart, Lung, and Blood Institute; National Center for Advancing Translational Sciences; Medical Research Council; Genentech; National Cancer Institute; Servier; Shionogi; Novo Nordisk Fonden; Novo Nordisk; Vertex Pharmaceuticals; Steno Diabetes Center Copenhagen; Wellcome Trust; National Institutes of Health; Regeneron Pharmaceuticals; Respicardia; Harvard University; U.S. Department of Health and Human Services; Kowa Company; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; National Institute on Aging; National Institute for Health and Care Research; Massachusetts General Hospital; GlaxoSmithKline; Guangdong Provincial People's Hospital; Eli Lilly and Company; Bristol-Myers Squibb; AstraZeneca; Amgen; Pfizer; Steno Diabetes Center Aarhus; McMaster University; Yale University","keywords":"Biology; Type 2 diabetes; Translation (biology); Genetics; Computational biology; Evolutionary biology; Type (biology); Genetic genealogy; Diabetes mellitus; Demography; Population; Gene; Sociology; Endocrinology; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003364322,0.001158718,0.00225139,0.002083997,0.0002892703,0.001463092,0.001384682,0.002178746,0.002420432],"category_scores_gemma":[0.004260421,0.0003562844,0.000763572,0.002338123,0.001195895,0.001592131,0.001288451,0.00389971,0.001236788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001144263,"about_ca_system_score_gemma":0.002073688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0028568,"about_ca_topic_score_gemma":0.004768014,"domain_scores_codex":[0.9994404,0.000173059,0.00006590668,0.0001053213,0.0001749368,0.00004040276],"domain_scores_gemma":[0.9963036,0.002757192,0.000152645,0.00009153603,0.0005332337,0.0001618691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0001568328,0.00004263371,0.0006323358,0.009364299,0.0003239273,0.0002058717,0.0000447826,0.0003360313,0.000534373,0.009636593,0.05032809,0.9283942],"study_design_scores_gemma":[0.00007499658,0.00008768314,0.002569691,0.008239713,0.0004657778,0.0009256038,0.00008842421,0.0001664672,0.0002120816,0.01374011,0.9733811,0.00004831847],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004036463,0.9977223,0.0002533337,0.001185168,0.0004758618,0.000002237377,0.00002418608,0.000006352643,0.0002901263],"genre_scores_gemma":[0.0003301608,0.9976925,0.0002938612,0.00078334,0.0006706149,0.000005219707,0.00002845384,0.000002051065,0.0001938143],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003364322,"threshold_uncertainty_score":0.01779246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06833353806244687,"score_gpt":0.3585684173584159,"score_spread":0.290234879295969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}