{"id":"W4280552587","doi":"10.1101/2022.05.11.491453","title":"Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; McGill University; Montreal Neurological Institute and Hospital","funders":"Medical Research Council; National Institute for Health and Care Research; Imperial College Healthcare NHS Trust; UK Dementia Research Institute; University of Oxford; Imperial College London","keywords":"Translocator protein; Microglia; Inflammation; Neuroscience; Biology; Human brain; Cell biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004326271,0.0003279856,0.0002552248,0.0006575023,0.0001470109,0.000319056,0.0001422943,0.0003732902,0.002140352],"category_scores_gemma":[0.0003526102,0.0001493292,0.0001574486,0.0002979087,0.0004952066,0.0002394009,0.000264697,0.0004431167,0.0004781341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462677,"about_ca_system_score_gemma":0.0001304247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002454907,"about_ca_topic_score_gemma":0.0002701282,"domain_scores_codex":[0.9996997,0.00005906361,0.00002739315,0.0000995352,0.00006439223,0.00004995059],"domain_scores_gemma":[0.9997243,0.00003034453,0.0001268498,0.00003658808,0.00003160193,0.00005037064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006201338,0.00006658828,0.005129293,0.0001406776,0.00004440265,0.000736515,0.0001107299,0.00004544384,0.9883173,0.0002931055,0.0002656274,0.004230035],"study_design_scores_gemma":[0.0001784952,0.002587798,0.2030038,0.0001484554,0.0002324132,0.04301704,0.000594617,0.0009870452,0.7275261,0.001619087,0.02007276,0.0000323721],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878333,0.004001073,0.005254699,0.0002210579,0.00006406178,0.0000376501,0.0005044694,0.000128361,0.00195544],"genre_scores_gemma":[0.9913201,0.001076289,0.00486198,0.0001033374,0.00002497271,0.00005339229,0.0009178477,0.00004833173,0.001593872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002140352,"threshold_uncertainty_score":0.007160187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03286184764076625,"score_gpt":0.2440636630096845,"score_spread":0.2112018153689182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}