{"id":"W4280553297","doi":"10.1016/j.isci.2022.104404","title":"cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model","year":2022,"lang":"en","type":"article","venue":"iScience","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"","keywords":"IRF3; Neuroinflammation; Bystander effect; Cell biology; SOD1; Interferon; Biology; Mitochondrion; Cytosol; Chemistry; Immunology; Innate immune system; Immune system; Inflammation; Gene; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00112993,0.0001012598,0.0001725486,0.0002476084,0.0002156194,0.00005579545,0.0002663457,0.00002778435,0.00007378573],"category_scores_gemma":[0.0006958869,0.00009017206,0.00002090781,0.0008427393,0.0001107329,0.0002363548,0.0007376365,0.0004518855,0.00002003739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002024229,"about_ca_system_score_gemma":0.0001400962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003588181,"about_ca_topic_score_gemma":0.00004396517,"domain_scores_codex":[0.9982994,0.0001347853,0.0002652554,0.0003325868,0.0006160268,0.0003519663],"domain_scores_gemma":[0.9993615,0.00006596825,0.00005218751,0.0002747453,0.00006784726,0.0001777575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00009402981,0.0000667468,0.006747776,0.00002485117,0.00000252636,0.00005794333,0.003598213,0.002458616,0.9645087,0.00006248114,0.00004171022,0.02233645],"study_design_scores_gemma":[0.00118005,0.0008193829,0.37486,0.0001380652,0.000009316404,0.00009287505,0.0003263624,0.612834,0.008694634,0.0005053076,0.0002973377,0.0002426944],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953589,0.0000511001,0.00056405,0.002995208,0.00004995935,0.0005591266,0.000004320656,0.00004196859,0.0003753427],"genre_scores_gemma":[0.9982976,0.00001266777,0.001023195,0.0002700213,0.00002091899,0.00005249726,0.000007203962,0.0000116268,0.0003043105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.955814,"threshold_uncertainty_score":0.367711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0429708570565162,"score_gpt":0.3010115821307945,"score_spread":0.2580407250742783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}